Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The Guidelines–Heart Failure registry

Justin B. Echouffo-Tcheugui, Haolin Xu, Adam D. DeVore, Phillip Schulte, Javed Butler, Clyde W. Yancy, Deepak L. Bhatt, Adrian F. Hernandez, Paul A. Heidenreich, Gregg C. Fonarow

Research output: Contribution to journalArticle

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Abstract

Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden. Methods Using data from the Get With the Guidelines–Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40% ≤ EF < 50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends. Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0% overall, 41.8% in HFrEF, 46.7% in HFbEF, 45.5% in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2%-45.8%; Ptrend < .0001), including among those with HFrEF (42.0%-43.6%; Ptrend < .0001), HFbEF (46.0%-49.2%; Ptrend < .0001), or HFpEF (43.6%-46.8%, Ptrend < .0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95% CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status. Conclusions Approximately 44% of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10 years, particularly among those patients with new-onset HFpEF.

Original languageEnglish (US)
Pages (from-to)9-20
Number of pages12
JournalAmerican Heart Journal
Volume182
DOIs
StatePublished - Dec 1 2016

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Registries
Diabetes Mellitus
Heart Failure
Hospital Mortality
Length of Stay
Odds Ratio
Quality of Health Care
Hospitalization
Logistic Models

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure : Findings from Get With The Guidelines–Heart Failure registry. / Echouffo-Tcheugui, Justin B.; Xu, Haolin; DeVore, Adam D.; Schulte, Phillip; Butler, Javed; Yancy, Clyde W.; Bhatt, Deepak L.; Hernandez, Adrian F.; Heidenreich, Paul A.; Fonarow, Gregg C.

In: American Heart Journal, Vol. 182, 01.12.2016, p. 9-20.

Research output: Contribution to journalArticle

Echouffo-Tcheugui, Justin B. ; Xu, Haolin ; DeVore, Adam D. ; Schulte, Phillip ; Butler, Javed ; Yancy, Clyde W. ; Bhatt, Deepak L. ; Hernandez, Adrian F. ; Heidenreich, Paul A. ; Fonarow, Gregg C. / Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure : Findings from Get With The Guidelines–Heart Failure registry. In: American Heart Journal. 2016 ; Vol. 182. pp. 9-20.
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abstract = "Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden. Methods Using data from the Get With the Guidelines–Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40{\%}), borderline EF (HFbEF; 40{\%} ≤ EF < 50{\%}), or preserved EF (HFpEF; EF ≥ 50{\%}), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends. Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0{\%} overall, 41.8{\%} in HFrEF, 46.7{\%} in HFbEF, 45.5{\%} in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2{\%}-45.8{\%}; Ptrend < .0001), including among those with HFrEF (42.0{\%}-43.6{\%}; Ptrend < .0001), HFbEF (46.0{\%}-49.2{\%}; Ptrend < .0001), or HFpEF (43.6{\%}-46.8{\%}, Ptrend < .0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95{\%} CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status. Conclusions Approximately 44{\%} of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10 years, particularly among those patients with new-onset HFpEF.",
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T1 - Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure

T2 - Findings from Get With The Guidelines–Heart Failure registry

AU - Echouffo-Tcheugui, Justin B.

AU - Xu, Haolin

AU - DeVore, Adam D.

AU - Schulte, Phillip

AU - Butler, Javed

AU - Yancy, Clyde W.

AU - Bhatt, Deepak L.

AU - Hernandez, Adrian F.

AU - Heidenreich, Paul A.

AU - Fonarow, Gregg C.

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N2 - Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden. Methods Using data from the Get With the Guidelines–Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40% ≤ EF < 50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends. Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0% overall, 41.8% in HFrEF, 46.7% in HFbEF, 45.5% in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2%-45.8%; Ptrend < .0001), including among those with HFrEF (42.0%-43.6%; Ptrend < .0001), HFbEF (46.0%-49.2%; Ptrend < .0001), or HFpEF (43.6%-46.8%, Ptrend < .0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95% CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status. Conclusions Approximately 44% of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10 years, particularly among those patients with new-onset HFpEF.

AB - Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden. Methods Using data from the Get With the Guidelines–Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40% ≤ EF < 50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends. Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0% overall, 41.8% in HFrEF, 46.7% in HFbEF, 45.5% in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2%-45.8%; Ptrend < .0001), including among those with HFrEF (42.0%-43.6%; Ptrend < .0001), HFbEF (46.0%-49.2%; Ptrend < .0001), or HFpEF (43.6%-46.8%, Ptrend < .0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95% CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status. Conclusions Approximately 44% of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10 years, particularly among those patients with new-onset HFpEF.

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