TY - JOUR
T1 - Temporal relationship between depressive symptoms and cognitive impairment
T2 - The italian longitudinal study on aging
AU - Panza, Francesco
AU - D'Introno, Alessia
AU - Colacicco, Anna M.
AU - Capurso, Cristiano
AU - Del Parigi, Angelo
AU - Caselli, Richard J.
AU - Frisardi, Vincenza
AU - Scapicchio, Pierluigi
AU - Chiloiro, Roberta
AU - Scafato, Emanuele
AU - Gandin, Claudia
AU - Vendemiale, Gianluigi
AU - Capurso, Antonio
AU - Solfrizzi, Vincenzo
PY - 2009
Y1 - 2009
N2 - The temporal relationship between depression and cognitive decline has not been extensively investigated in prospective population-based studies, and most of these have only looked in one direction. We estimated the bidirectional temporal relationship between depressive symptoms and cognitive function in older subjects, excluding subjects with a clinical diagnosis of dementia or mild cognitive impairment (MCI). In a total of 2,963 individuals from the Italian Longitudinal Study on Aging, depressive symptoms, global cognitive function, and episodic memory were measured. Dementia, Alzheimer's disease, vascular dementia, and MCI were classified using current clinical criteria. Depressive symptoms at baseline were associated with an accelerated global cognitive function decline and an accelerated rate of episodic memory delayed recall decline in a 3.5-year follow-up. Finally, an accelerated increase with time of depressive symptoms during the same follow-up period was not associated with global cognitive function and episodic memory (immediate and delayed recall). In older subjects non-cognitively impaired, depressive symptoms at baseline predicted change over time of global cognitive decline and episodic memory delayed recall. Global cognitive function and episodic memory at baseline were not associated with the course of depressive symptoms during the follow-up.
AB - The temporal relationship between depression and cognitive decline has not been extensively investigated in prospective population-based studies, and most of these have only looked in one direction. We estimated the bidirectional temporal relationship between depressive symptoms and cognitive function in older subjects, excluding subjects with a clinical diagnosis of dementia or mild cognitive impairment (MCI). In a total of 2,963 individuals from the Italian Longitudinal Study on Aging, depressive symptoms, global cognitive function, and episodic memory were measured. Dementia, Alzheimer's disease, vascular dementia, and MCI were classified using current clinical criteria. Depressive symptoms at baseline were associated with an accelerated global cognitive function decline and an accelerated rate of episodic memory delayed recall decline in a 3.5-year follow-up. Finally, an accelerated increase with time of depressive symptoms during the same follow-up period was not associated with global cognitive function and episodic memory (immediate and delayed recall). In older subjects non-cognitively impaired, depressive symptoms at baseline predicted change over time of global cognitive decline and episodic memory delayed recall. Global cognitive function and episodic memory at baseline were not associated with the course of depressive symptoms during the follow-up.
KW - Alzheimer's disease
KW - Cognitive aging
KW - Dementia
KW - Depression
KW - Memory disorders
UR - http://www.scopus.com/inward/record.url?scp=68949159713&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68949159713&partnerID=8YFLogxK
U2 - 10.3233/JAD-2009-1111
DO - 10.3233/JAD-2009-1111
M3 - Article
C2 - 19542612
AN - SCOPUS:68949159713
SN - 1387-2877
VL - 17
SP - 899
EP - 911
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 4
ER -