Temporal acoustic measures distinguish primary progressive apraxia of speech from primary progressive aphasia

Joseph R. Duffy, Holly Hanley, Rene Utianski, Heather Clark, Edythe Strand, Keith Anthony Josephs, Jennifer Lynn Whitwell

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The purpose of this study was to determine if acoustic measures of duration and syllable rate during word and sentence repetition, and a measure of within-word lexical stress, distinguish speakers with primary progressive apraxia of speech (PPAOS) from nonapraxic speakers with the agrammatic or logopenic variants of primary progressive aphasia (PPA), and control speakers. Results revealed that the PPAOS group had longer durations and reduced rate of syllable production for most words and sentences, and the measure of lexical stress. Sensitivity and specificity indices for the PPAOS versus the other groups were highest for longer multisyllabic words and sentences. For the PPAOS group, correlations between acoustic measures and perceptual ratings of AOS were moderately high to high. Several temporal measures used in this study may aid differential diagnosis and help quantify features of PPAOS that are distinct from those associated with PPA in which AOS is not present.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalBrain and Language
Volume168
DOIs
StatePublished - May 1 2017

Keywords

  • Acoustic analysis
  • Primary progressive aphasia
  • Primary progressive apraxia of speech

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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