TY - CHAP
T1 - Temperature and brain protection in cardiac surgery
AU - Djaiani, George
AU - Ramakrishna, Harish
AU - Grigore, Alina M.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - It is well known and has been clearly demonstrated that temperature plays a significant role in cerebral physiology and physiopathology, particularly in the setting of cardiac surgery with cardiopulmonary bypass (CPB). The human central nervous system (CNS) receives about 15% of the resting cardiac output and consumes about 20% of the oxygen required by the body at rest. The brain, which accounts for 2% of the total body weight, has an oxygen consumption of about 3.5 mL-1·100 g-1·min-1. This high metabolic rate mandates a high blood flow; therefore, cerebral blood flow (CBF) (Fig. 13.1) is of paramount importance and is normally under metabolic, neural, myogenic, and chemical control.1
AB - It is well known and has been clearly demonstrated that temperature plays a significant role in cerebral physiology and physiopathology, particularly in the setting of cardiac surgery with cardiopulmonary bypass (CPB). The human central nervous system (CNS) receives about 15% of the resting cardiac output and consumes about 20% of the oxygen required by the body at rest. The brain, which accounts for 2% of the total body weight, has an oxygen consumption of about 3.5 mL-1·100 g-1·min-1. This high metabolic rate mandates a high blood flow; therefore, cerebral blood flow (CBF) (Fig. 13.1) is of paramount importance and is normally under metabolic, neural, myogenic, and chemical control.1
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U2 - 10.1007/978-1-84996-293-3_13
DO - 10.1007/978-1-84996-293-3_13
M3 - Chapter
AN - SCOPUS:84892215101
SN - 9781849962926
SP - 141
EP - 157
BT - Brain Protection in Cardiac Surgery
PB - Springer London
ER -