Telomeres, senescence, oxidative stress, and heterogeneity

João F. Passos, Glyn Nelson, Thomas Von Zglinicki

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Life span heterogeneity is a hallmark of the ageing process. It is also a characteristic feature of telomere-dependent replicative senescence. We review here evidence showing that telomere shortening is heterogeneous between telomeres and between cells, and relate this to cell-to-cell variation in mitochondrial function and production of reactive oxygen species (ROS). Telomere shortening is to a large extent governed by ROS-mediated telomeric DNA damage, and we show here that apparently stochastic variation in mitochondrial ROS production can account for vast differences in replicative potential between individual cell lineages.

Original languageEnglish (US)
Title of host publicationTelomeres and Telomerase in Ageing, Disease, and Cancer
Subtitle of host publicationMolecular Mechanisms of Adult Stem Cell Ageing
PublisherSpringer Berlin Heidelberg
Pages43-56
Number of pages14
ISBN (Print)9783540737087
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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    Passos, J. F., Nelson, G., & Von Zglinicki, T. (2008). Telomeres, senescence, oxidative stress, and heterogeneity. In Telomeres and Telomerase in Ageing, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing (pp. 43-56). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-73709-4_3