Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma

Jong Y. Park, Hung N. Luu, Hyun Y. Park, Hui Yi Lin, Selina Radlein, Giuliano Di Pietro, Chang Dong Yeo, Seung Joon Kim, Nahyeon Kang, Samuel Antwi, Wade J. Sexton, Philippe E. Spiess, Shohreh Dickinson, Alexander Parker

Research output: Contribution to journalArticle

Abstract

Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case-control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results: As expected, increasing age was inversely correlated with RTL (Pearson r=-0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95% confidence interval (CI): 1.27-1.71] after adjustment for covariates. Conclusions: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC.

Original languageEnglish (US)
Pages (from-to)S397-S403
JournalTranslational Cancer Research
Volume8
DOIs
StatePublished - Jan 1 2019

Fingerprint

Telomere
Renal Cell Carcinoma
Leukocytes
Neoplasms
Odds Ratio
Chromosomal Instability
Early Detection of Cancer
Case-Control Studies
Real-Time Polymerase Chain Reaction
Carcinogenesis
Biomarkers
Logistic Models
Smoking
Regression Analysis
Confidence Intervals

Keywords

  • Renal cancer
  • Risk
  • Telomere length

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma. / Park, Jong Y.; Luu, Hung N.; Park, Hyun Y.; Lin, Hui Yi; Radlein, Selina; Di Pietro, Giuliano; Yeo, Chang Dong; Kim, Seung Joon; Kang, Nahyeon; Antwi, Samuel; Sexton, Wade J.; Spiess, Philippe E.; Dickinson, Shohreh; Parker, Alexander.

In: Translational Cancer Research, Vol. 8, 01.01.2019, p. S397-S403.

Research output: Contribution to journalArticle

Park, JY, Luu, HN, Park, HY, Lin, HY, Radlein, S, Di Pietro, G, Yeo, CD, Kim, SJ, Kang, N, Antwi, S, Sexton, WJ, Spiess, PE, Dickinson, S & Parker, A 2019, 'Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma', Translational Cancer Research, vol. 8, pp. S397-S403. https://doi.org/10.21037/tcr.2019.06.36
Park, Jong Y. ; Luu, Hung N. ; Park, Hyun Y. ; Lin, Hui Yi ; Radlein, Selina ; Di Pietro, Giuliano ; Yeo, Chang Dong ; Kim, Seung Joon ; Kang, Nahyeon ; Antwi, Samuel ; Sexton, Wade J. ; Spiess, Philippe E. ; Dickinson, Shohreh ; Parker, Alexander. / Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma. In: Translational Cancer Research. 2019 ; Vol. 8. pp. S397-S403.
@article{b24ab05f1d6943659205a47e7a890d66,
title = "Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma",
abstract = "Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case-control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results: As expected, increasing age was inversely correlated with RTL (Pearson r=-0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95{\%} confidence interval (CI): 1.27-1.71] after adjustment for covariates. Conclusions: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC.",
keywords = "Renal cancer, Risk, Telomere length",
author = "Park, {Jong Y.} and Luu, {Hung N.} and Park, {Hyun Y.} and Lin, {Hui Yi} and Selina Radlein and {Di Pietro}, Giuliano and Yeo, {Chang Dong} and Kim, {Seung Joon} and Nahyeon Kang and Samuel Antwi and Sexton, {Wade J.} and Spiess, {Philippe E.} and Shohreh Dickinson and Alexander Parker",
year = "2019",
month = "1",
day = "1",
doi = "10.21037/tcr.2019.06.36",
language = "English (US)",
volume = "8",
pages = "S397--S403",
journal = "Translational Cancer Research",
issn = "2218-676X",
publisher = "AME Publishing Company",

}

TY - JOUR

T1 - Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma

AU - Park, Jong Y.

AU - Luu, Hung N.

AU - Park, Hyun Y.

AU - Lin, Hui Yi

AU - Radlein, Selina

AU - Di Pietro, Giuliano

AU - Yeo, Chang Dong

AU - Kim, Seung Joon

AU - Kang, Nahyeon

AU - Antwi, Samuel

AU - Sexton, Wade J.

AU - Spiess, Philippe E.

AU - Dickinson, Shohreh

AU - Parker, Alexander

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case-control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results: As expected, increasing age was inversely correlated with RTL (Pearson r=-0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95% confidence interval (CI): 1.27-1.71] after adjustment for covariates. Conclusions: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC.

AB - Background: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. Methods: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case-control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. Results: As expected, increasing age was inversely correlated with RTL (Pearson r=-0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95% confidence interval (CI): 1.27-1.71] after adjustment for covariates. Conclusions: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC.

KW - Renal cancer

KW - Risk

KW - Telomere length

UR - http://www.scopus.com/inward/record.url?scp=85072321718&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072321718&partnerID=8YFLogxK

U2 - 10.21037/tcr.2019.06.36

DO - 10.21037/tcr.2019.06.36

M3 - Article

AN - SCOPUS:85072321718

VL - 8

SP - S397-S403

JO - Translational Cancer Research

JF - Translational Cancer Research

SN - 2218-676X

ER -