Telomere length and risk of major adverse cardiac events and cancer in obstructive sleep apnea patients

Katarzyna Polonis, Sreeja Sompalli, Christiane Becari, Jiang Xie, Naima Covassin, Phillip J. Schulte, Brooke R. Druliner, Ruth A. Johnson, Krzysztof Narkiewicz, Lisa A. Boardman, Prachi Singh, Virend K. Somers

Research output: Contribution to journalArticlepeer-review

Abstract

Telomere length (TL) is associated with cardiovascular disease (CVD) and cancer. Obstructive sleep apnea (OSA) is also linked to higher risk of CVD and cancer, and to TL. We investigated the association between TL and risk of major adverse cardiac events (MACE) and cancer in OSA patients. We studied 210 individuals undergoing sleep-related studies between 2000 and 2007. Baseline characteristics and follow-up data (available in 164 subjects) were obtained from clinic records. Incidence rates were calculated for the entire group and by OSA status. Hazard ratios were calculated to estimate effects of OSA and TL on risk of MACE and cancer. In total, 32 individuals (20%) developed MACE and/or cancer during 12.7-year follow-up. The OSA group had a higher likelihood of cancer (16.0 vs. 4.9 events per 1000 person-years, P = 0.044) but no clear evidence of an elevated incidence of MACE (10.8 vs. 4.8 events per 1000 person-years, P = 0.293) compared to the non-OSA group. There was no association between TL and MACE- (HR = 1.01, 95% CI 0.78–1.28), or cancer-risk (HR = 1.18, 95% CI 0.96–1.43). Our study warrants further investigation of any modulating effect of OSA on TL and the risk of MACE and cancer.

Original languageEnglish (US)
Article number381
JournalCells
Volume8
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • Cancer
  • Major adverse cardiac events
  • Obstructive sleep apnea
  • Telomere length

ASJC Scopus subject areas

  • Medicine(all)

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