Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello; Diana Jurk; João F. Passos; Fabrizio d’Adda di Fagagna

doi:10.1038/s41556-022-00842-x

Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello, Diana Jurk, João F. Passos, Fabrizio d’Adda di Fagagna

Physiology & Biomedical Engineering

Research output: Contribution to journal › Review article › peer-review

Abstract

Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.

Original language	English (US)
Pages (from-to)	135-147
Number of pages	13
Journal	Nature Cell Biology
Volume	24
Issue number	2
DOIs	https://doi.org/10.1038/s41556-022-00842-x
State	Published - Feb 2022

ASJC Scopus subject areas

Cell Biology

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abstract = "Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.",

author = "Francesca Rossiello and Diana Jurk and Passos, {Jo{\~a}o F.} and {d{\textquoteright}Adda di Fagagna}, Fabrizio",

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AB - Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.

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Telomere dysfunction in ageing and age-related diseases

Abstract

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