@article{c54e0178b7aa4d059b06e701f4f3e94b,
title = "Telomere dysfunction in ageing and age-related diseases",
abstract = "Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.",
author = "Francesca Rossiello and Diana Jurk and Passos, {Jo{\~a}o F.} and {d{\textquoteright}Adda di Fagagna}, Fabrizio",
note = "Funding Information: We thank S. Sepe, C. Tripodo and P. Kordowitzki for critically reading the manuscript. Funding in D.J.{\textquoteright}s laboratory was provided by grants R01AG 68182-1, the Ted Nash Long Life Foundation and P30DK084567. Funding in J.F.P.{\textquoteright}s laboratory was provided by grants 1R01AG 68048-1, 1UG3CA 268103-1, UL1TR 02377-1, the Ted Nash Long Life Foundation and P01 AG 62413-1. F.d{\textquoteright}A.d.F.{\textquoteright}s laboratory is supported by an ERC advanced grant (TELORNAGING–835103), AIRC-IG (21762), Telethon (GGP17111), AIRC 5×1000 (21091), an ERC PoC grant (FIREQUENCER–875139), Progetti di Ricerca di Interesse Nazionale (PRIN) 2015 “ATR and ATM-mediated control of chromosome integrity and cell plasticity”, Progetti di Ricerca di Interesse Nazionale (PRIN) 2017 “RNA and genome Instability”, Progetto AriSLA 2021 “DDR & ALS”, POR FESR 2014-2020 Regione Lombardia (InterSLA project), FRRB–Fondazione Regionale per la Ricerca Biomedica–under the frame of EJP RD, the European Joint Programme on Rare Diseases with funding from the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the EJP RD COFUND-EJP number 825575. Figure was originally created with BioRender.com . Funding Information: We thank S. Sepe, C. Tripodo and P. Kordowitzki for critically reading the manuscript. Funding in D.J.?s laboratory was provided by grants R01AG 68182-1, the Ted Nash Long Life Foundation and P30DK084567. Funding in J.F.P.?s laboratory was provided by grants 1R01AG 68048-1, 1UG3CA 268103-1, UL1TR 02377-1, the Ted Nash Long Life Foundation and P01 AG 62413-1. F.d?A.d.F.?s laboratory is supported by an ERC advanced grant (TELORNAGING?835103), AIRC-IG (21762), Telethon (GGP17111), AIRC 5?1000 (21091), an ERC PoC grant (FIREQUENCER?875139), Progetti di Ricerca di Interesse Nazionale (PRIN) 2015 ?ATR and ATM-mediated control of chromosome integrity and cell plasticity?, Progetti di Ricerca di Interesse Nazionale (PRIN) 2017 ?RNA and genome Instability?, Progetto AriSLA 2021 ?DDR & ALS?, POR FESR 2014-2020 Regione Lombardia (InterSLA project), FRRB?Fondazione Regionale per la Ricerca Biomedica?under the frame of EJP RD, the European Joint Programme on Rare Diseases with funding from the European Union?s Horizon 2020 research and innovation programme under the EJP RD COFUND-EJP number 825575. Figure 1 was originally created with BioRender.com. Publisher Copyright: {\textcopyright} 2022, Springer Nature Limited.",
year = "2022",
month = feb,
doi = "10.1038/s41556-022-00842-x",
language = "English (US)",
volume = "24",
pages = "135--147",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "2",
}