Technology insight: In vivo coronary plaque classification by intravascular ultrasonography radiofrequency analysis

Andreas König, M. Pauliina Margolis, Renu Virmani, David Holmes, Volker Klauss

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

Acute coronary syndromes or sudden coronary death are often the first manifestations of coronary artery disease. In the majority of patients, acute coronary syndrome events are caused by plaque rupture in flow-limiting and non-flow-limiting angiographically intermediate stenoses. Histopathologic analyses have shown that plaque composition is related to the occurrence of acute clinical events and, therefore, to the vulnerability of the plaque. The emerging importance of adaptive coronary remodeling processes, such as the compensatory enlargement of the coronary artery in response to initial lesion development, has focused our interest on the nonstenotic lesions of the coronary tree. In vivo intravascular ultrasonography can demonstrate the discrepancies between the actual extent of coronary atherosclerosis and that seen by angiographic imaging. The spectral analysis of intravascular ultrasonography derived radiofrequency data enables more precise analysis of plaque composition and type than grayscale intravascular ultrasonography.

Original languageEnglish (US)
Pages (from-to)219-229
Number of pages11
JournalNature Clinical Practice Cardiovascular Medicine
Volume5
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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