Abstract
Modulation of the normal immune response is the major challenge for successful organ transplantation. Cardiac allograft rejection is primarily the result of activation of T cells. Most currently used immunosuppressive agents mainly affect the T-cell-mediated limb of the immune system. Immunosuppressive strategies can be considered to have three goals: (1) prophylaxis against rejection early after cardiac transplantation, (2) long- term maintenance prophylaxis, and (3) treatment of acute rejection. The extent of immunosuppression needed varies with the time after transplantation and the rejection profile of the individual patient. The goal is to provide sufficient immunosuppression to retard rejection without causing undesirable side effects, including infection and neoplasms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 586-595 |
| Number of pages | 10 |
| Journal | Mayo Clinic Proceedings |
| Volume | 67 |
| Issue number | 6 |
| State | Published - 1992 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Techniques of immunosuppression after cardiac transplantation. / McGoon, M. D.; Frantz, Robert.
In: Mayo Clinic Proceedings, Vol. 67, No. 6, 1992, p. 586-595.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Techniques of immunosuppression after cardiac transplantation
AU - McGoon, M. D.
AU - Frantz, Robert
PY - 1992
Y1 - 1992
N2 - Modulation of the normal immune response is the major challenge for successful organ transplantation. Cardiac allograft rejection is primarily the result of activation of T cells. Most currently used immunosuppressive agents mainly affect the T-cell-mediated limb of the immune system. Immunosuppressive strategies can be considered to have three goals: (1) prophylaxis against rejection early after cardiac transplantation, (2) long- term maintenance prophylaxis, and (3) treatment of acute rejection. The extent of immunosuppression needed varies with the time after transplantation and the rejection profile of the individual patient. The goal is to provide sufficient immunosuppression to retard rejection without causing undesirable side effects, including infection and neoplasms.
AB - Modulation of the normal immune response is the major challenge for successful organ transplantation. Cardiac allograft rejection is primarily the result of activation of T cells. Most currently used immunosuppressive agents mainly affect the T-cell-mediated limb of the immune system. Immunosuppressive strategies can be considered to have three goals: (1) prophylaxis against rejection early after cardiac transplantation, (2) long- term maintenance prophylaxis, and (3) treatment of acute rejection. The extent of immunosuppression needed varies with the time after transplantation and the rejection profile of the individual patient. The goal is to provide sufficient immunosuppression to retard rejection without causing undesirable side effects, including infection and neoplasms.
UR - http://www.scopus.com/inward/record.url?scp=0026629037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026629037&partnerID=8YFLogxK
M3 - Review article
VL - 67
SP - 586
EP - 595
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
SN - 0025-6196
IS - 6
ER -