Abstract
Objectives The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy of vascular and interstitial tumor ablation. Methods This was a retrospective multicenter study including a cohort of fetuses with high-risk large SCTs between 2004 and 2010. In addition, we performed a systematic literature review of all cases that underwent tumor ablation in order to compare the survival rates after 'vascular' and 'interstitial' ablation. Statistical analysis was conducted using Bayesian methods. Results In our cohort, a total of 13 fetuses had high-risk large SCT and five of them underwent tumor ablation. The estimated difference in hydrops resolution rate between the fetal intervention and the no fetal intervention groups was 44.6% (95% credibility interval, 1.5 to 81.0%; Pdiff> 0 = 97.9%). The estimated difference in survival rate between the fetal intervention and the no fetal intervention groups was 31.0% (13.9 to 48.1%; Pdiff> 0 = 99.9%). We analyzed our five cases together with 28 cases from the literature and estimated the difference in survival rate between the vascular and interstitial ablation groups as 19.8% (-13.1 to 50.1%; Pdiff> 0 = 88.3%). The estimated difference in hydrops resolution rate between the vascular and the interstitial ablation groups was 36.7% (-5.7 to 72.7%; Pdiff> 0 = 95.5%). Conclusion Minimally invasive surgery seems to improve perinatal outcome in cases of high-risk large fetal SCT. Our findings suggest that 'vascular' ablation may improve outcome and may be more effective than 'interstitial' tumor ablation, but this hypothesis needs further investigation in a larger multicenter prospective study.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 712-719 |
| Number of pages | 8 |
| Journal | Ultrasound in Obstetrics and Gynecology |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2016 |
| Externally published | Yes |
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Keywords
- Fetal surgery
- Sacrococcygeal teratoma
- Tumor interstitial ablation
- Vascular ablation
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Reproductive Medicine
- Radiology Nuclear Medicine and imaging
- Obstetrics and Gynecology
Cite this
Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas : Cohort study and literature review. / Sananes, N.; Javadian, P.; Schwach Werneck Britto, I.; Meyer, N.; Koch, A.; Gaudineau, A.; Favre, R.; Ruano, Rodrigo.
In: Ultrasound in Obstetrics and Gynecology, Vol. 47, No. 6, 01.06.2016, p. 712-719.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Technical aspects and effectiveness of percutaneous fetal therapies for large sacrococcygeal teratomas
T2 - Cohort study and literature review
AU - Sananes, N.
AU - Javadian, P.
AU - Schwach Werneck Britto, I.
AU - Meyer, N.
AU - Koch, A.
AU - Gaudineau, A.
AU - Favre, R.
AU - Ruano, Rodrigo
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objectives The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy of vascular and interstitial tumor ablation. Methods This was a retrospective multicenter study including a cohort of fetuses with high-risk large SCTs between 2004 and 2010. In addition, we performed a systematic literature review of all cases that underwent tumor ablation in order to compare the survival rates after 'vascular' and 'interstitial' ablation. Statistical analysis was conducted using Bayesian methods. Results In our cohort, a total of 13 fetuses had high-risk large SCT and five of them underwent tumor ablation. The estimated difference in hydrops resolution rate between the fetal intervention and the no fetal intervention groups was 44.6% (95% credibility interval, 1.5 to 81.0%; Pdiff> 0 = 97.9%). The estimated difference in survival rate between the fetal intervention and the no fetal intervention groups was 31.0% (13.9 to 48.1%; Pdiff> 0 = 99.9%). We analyzed our five cases together with 28 cases from the literature and estimated the difference in survival rate between the vascular and interstitial ablation groups as 19.8% (-13.1 to 50.1%; Pdiff> 0 = 88.3%). The estimated difference in hydrops resolution rate between the vascular and the interstitial ablation groups was 36.7% (-5.7 to 72.7%; Pdiff> 0 = 95.5%). Conclusion Minimally invasive surgery seems to improve perinatal outcome in cases of high-risk large fetal SCT. Our findings suggest that 'vascular' ablation may improve outcome and may be more effective than 'interstitial' tumor ablation, but this hypothesis needs further investigation in a larger multicenter prospective study.
AB - Objectives The objectives of this study were to evaluate the efficacy of minimally invasive ablation of high-risk large sacrococcygeal teratomas (SCT) and to compare the efficacy of vascular and interstitial tumor ablation. Methods This was a retrospective multicenter study including a cohort of fetuses with high-risk large SCTs between 2004 and 2010. In addition, we performed a systematic literature review of all cases that underwent tumor ablation in order to compare the survival rates after 'vascular' and 'interstitial' ablation. Statistical analysis was conducted using Bayesian methods. Results In our cohort, a total of 13 fetuses had high-risk large SCT and five of them underwent tumor ablation. The estimated difference in hydrops resolution rate between the fetal intervention and the no fetal intervention groups was 44.6% (95% credibility interval, 1.5 to 81.0%; Pdiff> 0 = 97.9%). The estimated difference in survival rate between the fetal intervention and the no fetal intervention groups was 31.0% (13.9 to 48.1%; Pdiff> 0 = 99.9%). We analyzed our five cases together with 28 cases from the literature and estimated the difference in survival rate between the vascular and interstitial ablation groups as 19.8% (-13.1 to 50.1%; Pdiff> 0 = 88.3%). The estimated difference in hydrops resolution rate between the vascular and the interstitial ablation groups was 36.7% (-5.7 to 72.7%; Pdiff> 0 = 95.5%). Conclusion Minimally invasive surgery seems to improve perinatal outcome in cases of high-risk large fetal SCT. Our findings suggest that 'vascular' ablation may improve outcome and may be more effective than 'interstitial' tumor ablation, but this hypothesis needs further investigation in a larger multicenter prospective study.
KW - Fetal surgery
KW - Sacrococcygeal teratoma
KW - Tumor interstitial ablation
KW - Vascular ablation
UR - http://www.scopus.com/inward/record.url?scp=84971507061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84971507061&partnerID=8YFLogxK
U2 - 10.1002/uog.14935
DO - 10.1002/uog.14935
M3 - Review article
C2 - 26138446
AN - SCOPUS:84971507061
VL - 47
SP - 712
EP - 719
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
SN - 0960-7692
IS - 6
ER -