Technical and safety performance of CT-guided percutaneous microwave ablation for lung tumors: an ablate and resect study

Shanda H. Blackmon, Rosalie M. Sterner, Patrick W. Eiken, Thomas J. Vogl, Bradley B. Pua, Jeffrey L. Port, Damian E. Dupuy, Matthew R. Callstrom

Research output: Contribution to journalArticlepeer-review


Background: Percutaneous image-guided thermal ablation has an increasing role in the treatment of primary and metastatic lung tumors. Achieving acceptable clinical outcomes requires better tools for pre-procedure prediction of ablation zone size and shape. Methods: This was a prospective, non-randomized, single-arm, multicenter study conducted by Medtronic ( ID: NCT02323854). Subjects scheduled for resection of metastatic or primary lung nodules underwent preoperative percutaneous microwave ablation. Ablation zones as measured via CT imaging following ablation immediately and before resection surgically versus predicted ablation zones as prescribed by the investigational system software were compared. This CT scan occurred after the ablation was finished but the antenna still in position. Time (minutes) from antenna placement to removal was 23.7±13.1 (n=14); median: 21.0 (range, 6.0 to 48.0). The definition of the secondary endpoint of complete ablation was 100% non-viable tumor cells based on nicotinamide adenine dinucleotide hydrogen (NADH) staining. Safety endpoints were type, incidence, and severity of adverse events. Results: Fifteen patients (mean age 58.9 years; 67% male; 33% female) were enrolled in the study, 33.3% (5/15) with previous thoracic surgery, 73% (11/15) with metastasis, and 27% (4/15) with primary lung tumors. All underwent percutaneous microwave ablation followed by surgical resection the same day. Complete ablation was detected in 54.4% (6/11), incomplete ablation in 36.4% (4/11), and delayed necrosis in 9.1% (1/11). There were no device-related adverse events. Ablation zone volume was overestimated in all patients. Conclusions: Histological complete ablation was observed in 55% of subjects. CT scanning less than an hour after ablation and tissue shrinkage may account for the smaller zone of ablation observed compared to predicted by the investigational system software.

Original languageEnglish (US)
Pages (from-to)6827-6837
Number of pages11
JournalJournal of Thoracic Disease
Issue number12
StatePublished - Dec 2021


  • Ablation
  • Lung ablation
  • Lung cancer
  • Metastasis
  • Metastectomy
  • Microwave ablation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Technical and safety performance of CT-guided percutaneous microwave ablation for lung tumors: an ablate and resect study'. Together they form a unique fingerprint.

Cite this