Technetium-99m MIBI to assess coronary collateral flow during acute myocardial infarction in two closed-chest animal models

Timothy F. Christian, Michael K. O'Connor, Robert S. Schwartz, Raymond J. Gibbons, Erik L. Ritman

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Collateral flow is an independent determinant of infarct size in both animal and clinical studies of myocardial infarction. The purpose of this study was to quantitatively evaluate, in a closed-chest animal model, a noninvasive method of measuring coronary collateral flow over a wide spectrum of collateral flow rates from a tracer that can be injected during occlusion but measured after reperfusion. Methods: Fourteen animals underwent 40 min of coronary occlusion using a closed-chest technique. Two closed-chest models representing different rates of collateral flow were used: canine and porcine. Coronary blood flow was measured by radiolabeled microspheres. Collateral blood within the risk zone was estimated from the severity of 99mTc-sestamibi tomographic perfusion defect. Results: Collateral blood flow was significantly higher in the canine model than it was in the porcine model. There was close agreement (r = 0.90) between absolute collateral flow by microspheres and the severity of the tomographic perfusion defect. Conclusion: These results suggest that an accurate noninvasive estimate of collateral blood flow can be provided by an intravenous injection of 99mTc-sestamibi.

Original languageEnglish (US)
Pages (from-to)1840-1846
Number of pages7
JournalJournal of Nuclear Medicine
Volume38
Issue number12
StatePublished - Dec 1 1997

Keywords

  • Collateral circulation
  • Coronary blood flow
  • Radionuclide imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Christian, T. F., O'Connor, M. K., Schwartz, R. S., Gibbons, R. J., & Ritman, E. L. (1997). Technetium-99m MIBI to assess coronary collateral flow during acute myocardial infarction in two closed-chest animal models. Journal of Nuclear Medicine, 38(12), 1840-1846.