Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition

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Abstract

Introduction Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)–related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30–49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropriately to capture regional Alzheimer-specific (i.e., amyloid sensitive) tau-PET changes in individuals aged 50+ years. Methods We identified 490 individuals (70 between 30–49 years as a reference group and 420 cognitively normal between 50–95 years of age) with tau-PET and amyloid PET scans from the Mayo Clinic Study of Aging. Results There was intrinsic regional variability in average tau-PET SUVR with uptakes higher in some regions than others, even in the younger individuals who would have minimal or no neurofibrillary tangles. We corrected for this using region of interest–specific z-scores based on the reference group. Amyloid and tau-PET uptake were associated throughout the brain after adjusting for age, with the highest correlations in the medial temporal regions. Discussion Regions with high-average SUVR are not necessarily those with the greatest tau pathology. Standardization is therefore recommended. Standardization of the data “realigns” the data such that the regional tau z-scores are informative of the disease process, that is, regions with high z-scores now coincide with regions correlated with amyloid deposition. Medial temporal structures, specifically entorhinal cortex–tau, may be useful as an AD-specific tau-PET signature due to its sensitivity to amyloid.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume6
DOIs
StatePublished - 2017

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Amyloid
Positron-Emission Tomography
Alzheimer Disease
Neurofibrillary Tangles
Brain
Temporal Lobe
Pathology
Population

Keywords

  • Alzheimer disease
  • Amyloid imaging
  • Tau imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

@article{d0bfd557a3dd4a33a50697868a7cba3f,
title = "Tau-PET uptake: Regional variation in average SUVR and impact of amyloid deposition",
abstract = "Introduction Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)–related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30–49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropriately to capture regional Alzheimer-specific (i.e., amyloid sensitive) tau-PET changes in individuals aged 50+ years. Methods We identified 490 individuals (70 between 30–49 years as a reference group and 420 cognitively normal between 50–95 years of age) with tau-PET and amyloid PET scans from the Mayo Clinic Study of Aging. Results There was intrinsic regional variability in average tau-PET SUVR with uptakes higher in some regions than others, even in the younger individuals who would have minimal or no neurofibrillary tangles. We corrected for this using region of interest–specific z-scores based on the reference group. Amyloid and tau-PET uptake were associated throughout the brain after adjusting for age, with the highest correlations in the medial temporal regions. Discussion Regions with high-average SUVR are not necessarily those with the greatest tau pathology. Standardization is therefore recommended. Standardization of the data “realigns” the data such that the regional tau z-scores are informative of the disease process, that is, regions with high z-scores now coincide with regions correlated with amyloid deposition. Medial temporal structures, specifically entorhinal cortex–tau, may be useful as an AD-specific tau-PET signature due to its sensitivity to amyloid.",
keywords = "Alzheimer disease, Amyloid imaging, Tau imaging",
author = "Vemuri, {Prashanthi D} and Val Lowe and Knopman, {David S} and Senjem, {Matthew L.} and Kemp, {Bradley J.} and Christopher Schwarz and Przybelski, {Scott A.} and Machulda, {Mary Margaret} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.}",
year = "2017",
doi = "10.1016/j.dadm.2016.12.010",
language = "English (US)",
volume = "6",
pages = "21--30",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Tau-PET uptake

T2 - Regional variation in average SUVR and impact of amyloid deposition

AU - Vemuri, Prashanthi D

AU - Lowe, Val

AU - Knopman, David S

AU - Senjem, Matthew L.

AU - Kemp, Bradley J.

AU - Schwarz, Christopher

AU - Przybelski, Scott A.

AU - Machulda, Mary Margaret

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

PY - 2017

Y1 - 2017

N2 - Introduction Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)–related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30–49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropriately to capture regional Alzheimer-specific (i.e., amyloid sensitive) tau-PET changes in individuals aged 50+ years. Methods We identified 490 individuals (70 between 30–49 years as a reference group and 420 cognitively normal between 50–95 years of age) with tau-PET and amyloid PET scans from the Mayo Clinic Study of Aging. Results There was intrinsic regional variability in average tau-PET SUVR with uptakes higher in some regions than others, even in the younger individuals who would have minimal or no neurofibrillary tangles. We corrected for this using region of interest–specific z-scores based on the reference group. Amyloid and tau-PET uptake were associated throughout the brain after adjusting for age, with the highest correlations in the medial temporal regions. Discussion Regions with high-average SUVR are not necessarily those with the greatest tau pathology. Standardization is therefore recommended. Standardization of the data “realigns” the data such that the regional tau z-scores are informative of the disease process, that is, regions with high z-scores now coincide with regions correlated with amyloid deposition. Medial temporal structures, specifically entorhinal cortex–tau, may be useful as an AD-specific tau-PET signature due to its sensitivity to amyloid.

AB - Introduction Tau-positron emission tomography (PET) imaging with AV1451 is sensitive to Alzheimer disease (AD)–related tau deposition in the brain. We (1) examined regional variation of average tau-PET standardized uptake value ratios (SUVRs) in a young normal population (30–49 years) and corrected for the regional variability and (2) tested if the standardized values (z-scores) scaled appropriately to capture regional Alzheimer-specific (i.e., amyloid sensitive) tau-PET changes in individuals aged 50+ years. Methods We identified 490 individuals (70 between 30–49 years as a reference group and 420 cognitively normal between 50–95 years of age) with tau-PET and amyloid PET scans from the Mayo Clinic Study of Aging. Results There was intrinsic regional variability in average tau-PET SUVR with uptakes higher in some regions than others, even in the younger individuals who would have minimal or no neurofibrillary tangles. We corrected for this using region of interest–specific z-scores based on the reference group. Amyloid and tau-PET uptake were associated throughout the brain after adjusting for age, with the highest correlations in the medial temporal regions. Discussion Regions with high-average SUVR are not necessarily those with the greatest tau pathology. Standardization is therefore recommended. Standardization of the data “realigns” the data such that the regional tau z-scores are informative of the disease process, that is, regions with high z-scores now coincide with regions correlated with amyloid deposition. Medial temporal structures, specifically entorhinal cortex–tau, may be useful as an AD-specific tau-PET signature due to its sensitivity to amyloid.

KW - Alzheimer disease

KW - Amyloid imaging

KW - Tau imaging

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U2 - 10.1016/j.dadm.2016.12.010

DO - 10.1016/j.dadm.2016.12.010

M3 - Article

AN - SCOPUS:85009909847

VL - 6

SP - 21

EP - 30

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

SN - 2352-8729

ER -