Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

Bart Dermaut, Samir Kumar-Singh, Rosa V Rademakers, Jessie Theuns, Marc Cruts, Christine Van Broeckhoven

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.

Original languageEnglish (US)
Pages (from-to)664-672
Number of pages9
JournalTrends in Genetics
Volume21
Issue number12
DOIs
StatePublished - Dec 2005
Externally publishedYes

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Frontotemporal Dementia
Alzheimer Disease
Brain Diseases
Dissection
Molecular Biology
Genotype
Phenotype

ASJC Scopus subject areas

  • Genetics

Cite this

Dermaut, B., Kumar-Singh, S., Rademakers, R. V., Theuns, J., Cruts, M., & Van Broeckhoven, C. (2005). Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum. Trends in Genetics, 21(12), 664-672. https://doi.org/10.1016/j.tig.2005.09.005

Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum. / Dermaut, Bart; Kumar-Singh, Samir; Rademakers, Rosa V; Theuns, Jessie; Cruts, Marc; Van Broeckhoven, Christine.

In: Trends in Genetics, Vol. 21, No. 12, 12.2005, p. 664-672.

Research output: Contribution to journalArticle

Dermaut, B, Kumar-Singh, S, Rademakers, RV, Theuns, J, Cruts, M & Van Broeckhoven, C 2005, 'Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum', Trends in Genetics, vol. 21, no. 12, pp. 664-672. https://doi.org/10.1016/j.tig.2005.09.005
Dermaut, Bart ; Kumar-Singh, Samir ; Rademakers, Rosa V ; Theuns, Jessie ; Cruts, Marc ; Van Broeckhoven, Christine. / Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum. In: Trends in Genetics. 2005 ; Vol. 21, No. 12. pp. 664-672.
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