Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum

Bart Dermaut, Samir Kumar-Singh, Rosa Rademakers, Jessie Theuns, Marc Cruts, Christine Van Broeckhoven

Research output: Contribution to journalReview article

53 Scopus citations

Abstract

In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative brain disorders in which tau appears to be the central player.

Original languageEnglish (US)
Pages (from-to)664-672
Number of pages9
JournalTrends in Genetics
Volume21
Issue number12
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Genetics

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    Dermaut, B., Kumar-Singh, S., Rademakers, R., Theuns, J., Cruts, M., & Van Broeckhoven, C. (2005). Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum. Trends in Genetics, 21(12), 664-672. https://doi.org/10.1016/j.tig.2005.09.005