Targeting the stroma in pancreatic cancer

Daniel H. Ahn; Ramesh K. Ramanathan

doi:10.21037/cco.2017.11.02

Targeting the stroma in pancreatic cancer

Daniel H. Ahn, Ramesh K. Ramanathan

Hematology/Oncology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.

Original language	English (US)
Article number	65
Journal	Chinese clinical oncology
Volume	6
Issue number	6
DOIs	https://doi.org/10.21037/cco.2017.11.02
State	Published - Dec 1 2017

Keywords

Immunotherapy
Microenvironment
Pancreatic cancer
Stroma
Targeted therapies

ASJC Scopus subject areas

Oncology

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10.21037/cco.2017.11.02

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title = "Targeting the stroma in pancreatic cancer",

abstract = "The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.",

keywords = "Immunotherapy, Microenvironment, Pancreatic cancer, Stroma, Targeted therapies",

author = "Ahn, {Daniel H.} and Ramanathan, {Ramesh K.}",

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AU - Ahn, Daniel H.

AU - Ramanathan, Ramesh K.

N1 - Publisher Copyright: © Chinese Clinical Oncology.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.

AB - The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.

KW - Immunotherapy

KW - Microenvironment

KW - Pancreatic cancer

KW - Stroma

KW - Targeted therapies

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ER -

Targeting the stroma in pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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