Targeting the stroma in pancreatic cancer

Research output: Contribution to journalReview article

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Abstract

The tumor stroma in pancreatic adenocarcinoma is recognized as an integral component in tumorigenesis through its effects on cell signaling, immunosuppression and inhibitory effect on therapeutic agents. Promising preclinical activity has been observed with novel therapeutic agents that target the tumor microenvironment and represent one of many potential treatment strategies of interest in this disease. Herein, we will highlight and review therapeutic novel agents aimed at tumor stroma in pancreas cancer.

Original languageEnglish (US)
Article number65
JournalChinese Clinical Oncology
Volume6
Issue number6
DOIs
StatePublished - Dec 1 2017

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Keywords

  • Immunotherapy
  • Microenvironment
  • Pancreatic cancer
  • Stroma
  • Targeted therapies

ASJC Scopus subject areas

  • Oncology

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