Targeting the hypoxia pathway to treat pancreatic cancer

Lori A. Erickson; W. Edward Highsmith; Peiwen Fei; Jun Zhang

doi:10.2147/DDDT.S80888

Targeting the hypoxia pathway to treat pancreatic cancer

Lori A. Erickson, W. Edward Highsmith, Peiwen Fei, Jun Zhang

Laboratory Medicine and Pathology

Research output: Contribution to journal › Comment/debate › peer-review

20 Scopus citations

Abstract

The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.

Original language	English (US)
Pages (from-to)	2029-2031
Number of pages	3
Journal	Drug Design, Development and Therapy
Volume	9
DOIs	https://doi.org/10.2147/DDDT.S80888
State	Published - Apr 8 2015

Keywords

HIF-1
Hypoxia
Pancreatic cancer

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science
Drug Discovery

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10.2147/DDDT.S80888

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title = "Targeting the hypoxia pathway to treat pancreatic cancer",

abstract = "The correlation between hypoxia and pancreatic cancer has long been discussed. Hao{\textquoteright}s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao{\textquoteright}s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.",

keywords = "HIF-1, Hypoxia, Pancreatic cancer",

author = "Erickson, {Lori A.} and {Edward Highsmith}, W. and Peiwen Fei and Jun Zhang",

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doi = "10.2147/DDDT.S80888",

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AU - Erickson, Lori A.

AU - Edward Highsmith, W.

AU - Fei, Peiwen

AU - Zhang, Jun

PY - 2015/4/8

Y1 - 2015/4/8

N2 - The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.

AB - The correlation between hypoxia and pancreatic cancer has long been discussed. Hao’s research team made many efforts on revealing the oncogenic function of hypoxic inducible factor-1 (HIF-1) in pancreatic cancer progression and development in recent years. Based on their research, they linked micro-environmental regulation of pancreatic cancer and its clinical significance. Hao’s research team suggests it is a promising approach to target HIF-1 for the management of pancreatic cancer progression and invasion.

KW - HIF-1

KW - Hypoxia

KW - Pancreatic cancer

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SP - 2029

EP - 2031

JO - Drug Design, Development and Therapy

JF - Drug Design, Development and Therapy

ER -

Targeting the hypoxia pathway to treat pancreatic cancer

Abstract

Keywords

ASJC Scopus subject areas

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