Targeting retrovirus entry

F. L. Cosset, S. J. Russell

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations

Abstract

Most of the clinical gene therapy trials that have been initiated to date have employed ex vivo strategies in which cells are genetically modified outside the body and reimplanted. The ability to deliver genes accurately and efficiently to selected target cell populations in vivo would greatly expand the scope of gene therapy, but current vectors are not well suited to this task. Here we review recent attempts to develop retroviral vectors incorporating engineered envelope glycoproteins that are capable of delivering their genes in a highly specific manner to selected human target cells.

Original languageEnglish (US)
Pages (from-to)946-956
Number of pages11
JournalGene Therapy
Volume3
Issue number11
StatePublished - Jan 1 1996

Keywords

  • Gene delivery
  • Gene therapy
  • Retroviral display
  • Retroviral vectors
  • Targeting

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics

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