Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno, Eynav Klechevsky, Nathalie Schmitt, Ling Ni, Anne Laure Flamar, Sandra Zurawski, Gerard Zurawski, Karolina Palucka, Jacques Banchereau, SangKon Oh

Research output: Contribution to journalReview article

56 Citations (Scopus)

Abstract

Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

Original languageEnglish (US)
Pages (from-to)21-27
Number of pages7
JournalSeminars in Immunology
Volume23
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

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Dendritic Cells
Vaccines
Adaptive Immunity
Cell Biology
Spleen
Phenotype
Health
Population

Keywords

  • Antibody responses
  • Cytotoxic T lymphocyte responses
  • DC targeting
  • Dendritic cell subsets
  • Human
  • Vaccines

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Ueno, H., Klechevsky, E., Schmitt, N., Ni, L., Flamar, A. L., Zurawski, S., ... Oh, S. (2011). Targeting human dendritic cell subsets for improved vaccines. Seminars in Immunology, 23(1), 21-27. https://doi.org/10.1016/j.smim.2011.01.004

Targeting human dendritic cell subsets for improved vaccines. / Ueno, Hideki; Klechevsky, Eynav; Schmitt, Nathalie; Ni, Ling; Flamar, Anne Laure; Zurawski, Sandra; Zurawski, Gerard; Palucka, Karolina; Banchereau, Jacques; Oh, SangKon.

In: Seminars in Immunology, Vol. 23, No. 1, 01.02.2011, p. 21-27.

Research output: Contribution to journalReview article

Ueno, H, Klechevsky, E, Schmitt, N, Ni, L, Flamar, AL, Zurawski, S, Zurawski, G, Palucka, K, Banchereau, J & Oh, S 2011, 'Targeting human dendritic cell subsets for improved vaccines', Seminars in Immunology, vol. 23, no. 1, pp. 21-27. https://doi.org/10.1016/j.smim.2011.01.004
Ueno H, Klechevsky E, Schmitt N, Ni L, Flamar AL, Zurawski S et al. Targeting human dendritic cell subsets for improved vaccines. Seminars in Immunology. 2011 Feb 1;23(1):21-27. https://doi.org/10.1016/j.smim.2011.01.004
Ueno, Hideki ; Klechevsky, Eynav ; Schmitt, Nathalie ; Ni, Ling ; Flamar, Anne Laure ; Zurawski, Sandra ; Zurawski, Gerard ; Palucka, Karolina ; Banchereau, Jacques ; Oh, SangKon. / Targeting human dendritic cell subsets for improved vaccines. In: Seminars in Immunology. 2011 ; Vol. 23, No. 1. pp. 21-27.
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