Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno; Eynav Klechevsky; Nathalie Schmitt; Ling Ni; Anne Laure Flamar; Sandra Zurawski; Gerard Zurawski; Karolina Palucka; Jacques Banchereau; Sang Kon Oh

doi:10.1016/j.smim.2011.01.004

Targeting human dendritic cell subsets for improved vaccines

Hideki Ueno, Eynav Klechevsky, Nathalie Schmitt, Ling Ni, Anne Laure Flamar, Sandra Zurawski, Gerard Zurawski, Karolina Palucka, Jacques Banchereau, Sang Kon Oh

Allergy, Asthma and Clinical Immunology

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

Original language	English (US)
Pages (from-to)	21-27
Number of pages	7
Journal	Seminars in immunology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2011.01.004
State	Published - Feb 2011

Keywords

Antibody responses
Cytotoxic T lymphocyte responses
DC targeting
Dendritic cell subsets
Human
Vaccines

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.smim.2011.01.004

Cite this

@article{f24aa287dec84bb8af3bc4875c9fdccc,

title = "Targeting human dendritic cell subsets for improved vaccines",

abstract = "Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.",

keywords = "Antibody responses, Cytotoxic T lymphocyte responses, DC targeting, Dendritic cell subsets, Human, Vaccines",

author = "Hideki Ueno and Eynav Klechevsky and Nathalie Schmitt and Ling Ni and Flamar, {Anne Laure} and Sandra Zurawski and Gerard Zurawski and Karolina Palucka and Jacques Banchereau and Oh, {Sang Kon}",

year = "2011",

month = feb,

doi = "10.1016/j.smim.2011.01.004",

language = "English (US)",

volume = "23",

pages = "21--27",

journal = "Seminars in immunology",

issn = "1044-5323",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Targeting human dendritic cell subsets for improved vaccines

AU - Ueno, Hideki

AU - Klechevsky, Eynav

AU - Schmitt, Nathalie

AU - Ni, Ling

AU - Flamar, Anne Laure

AU - Zurawski, Sandra

AU - Zurawski, Gerard

AU - Palucka, Karolina

AU - Banchereau, Jacques

AU - Oh, Sang Kon

PY - 2011/2

Y1 - 2011/2

N2 - Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

AB - Dendritic cells (DCs) were discovered in 1973 by Ralph Steinman as a previously undefined cell type in the mouse spleen and are now recognized as a group of related cell populations that induce and regulate adaptive immune responses. Studies of the past decade show that, both in mice and humans, DCs are composed of subsets that differ in their localization, phenotype, and functions. These progresses in our understanding of DC biology provide a new framework for improving human health. In this review, we discuss human DC subsets in the context of their medical applications, with a particular focus on DC targeting.

KW - Antibody responses

KW - Cytotoxic T lymphocyte responses

KW - DC targeting

KW - Dendritic cell subsets

KW - Human

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=79952441518&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952441518&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2011.01.004

DO - 10.1016/j.smim.2011.01.004

M3 - Review article

C2 - 21277223

AN - SCOPUS:79952441518

SN - 1044-5323

VL - 23

SP - 21

EP - 27

JO - Seminars in immunology

JF - Seminars in immunology

IS - 1

ER -

Targeting human dendritic cell subsets for improved vaccines

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this