Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).
- Solute Carrier Family 9 Member A6 (SLC9A6)
- drug partitioning
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research