Targeting endosomal pH for cancer chemotherapy

Fabrice Lucien; Roxane R. Lavoie; Claire M. Dubois

doi:10.1080/23723556.2018.1435184

Targeting endosomal pH for cancer chemotherapy

Fabrice Lucien, Roxane R. Lavoie, Claire M. Dubois

Urology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).

Original language	English (US)
Article number	e1435184
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2018.1435184
State	Published - May 4 2018

Keywords

NHE6
Solute Carrier Family 9 Member A6 (SLC9A6)
chemoresistance
drug partitioning
endosomes
pH-regulation

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2018.1435184

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title = "Targeting endosomal pH for cancer chemotherapy",

abstract = "Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).",

keywords = "NHE6, Solute Carrier Family 9 Member A6 (SLC9A6), chemoresistance, drug partitioning, endosomes, pH-regulation",

author = "Fabrice Lucien and Lavoie, {Roxane R.} and Dubois, {Claire M.}",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Fabrice Lucien, Roxane R. Lavoie and Claire M. Dubois.",

year = "2018",

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doi = "10.1080/23723556.2018.1435184",

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T1 - Targeting endosomal pH for cancer chemotherapy

AU - Lucien, Fabrice

AU - Lavoie, Roxane R.

AU - Dubois, Claire M.

PY - 2018/5/4

Y1 - 2018/5/4

N2 - Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).

AB - Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).

KW - NHE6

KW - Solute Carrier Family 9 Member A6 (SLC9A6)

KW - chemoresistance

KW - drug partitioning

KW - endosomes

KW - pH-regulation

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DO - 10.1080/23723556.2018.1435184

M3 - Article

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 3

M1 - e1435184

ER -

Targeting endosomal pH for cancer chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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