Targeting endosomal pH for cancer chemotherapy

Fabrice Lucien, Roxane R. Lavoie, Claire M. Dubois

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).

Original languageEnglish (US)
Article numbere1435184
JournalMolecular and Cellular Oncology
Volume5
Issue number3
DOIs
StatePublished - May 4 2018

Keywords

  • NHE6
  • Solute Carrier Family 9 Member A6 (SLC9A6)
  • chemoresistance
  • drug partitioning
  • endosomes
  • pH-regulation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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