@article{88467ff8de474edc83b7928609fe7f6e,
title = "Targeting endosomal pH for cancer chemotherapy",
abstract = "Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).",
keywords = "NHE6, Solute Carrier Family 9 Member A6 (SLC9A6), chemoresistance, drug partitioning, endosomes, pH-regulation",
author = "Fabrice Lucien and Lavoie, {Roxane R.} and Dubois, {Claire M.}",
note = "Funding Information: This work was supported by the Canadian Institute of Health research, (MOP-126173) and an internal (UdeS/Merck Sharp & Dohme) operating grant. Funding Information: This work was supported by the Canadian Institutes of Health Research (CIHR) Grant MOP-126173 (to CMD) and an internal UdeS/Merck Sharp & Dohme operating grant. CMD is a member of the Fonds de la Recherche en Sant{\'e}du Qu{\'e}bec-funded Centre de Recherche Clinique du Centre Hos-pitalier Universitaire de Sherbrooke. Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2018, {\textcopyright} Fabrice Lucien, Roxane R. Lavoie and Claire M. Dubois.",
year = "2018",
month = may,
day = "4",
doi = "10.1080/23723556.2018.1435184",
language = "English (US)",
volume = "5",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
number = "3",
}