Targeting deregulated epigenetic control in cancer

Sayyed K. Zaidi, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Cancer is a multifaceted disease that involves acquisition of genetic mutations, deletions, and amplifications as well as deregulation of epigenetic mechanisms that fine-tune gene regulation. Key epigenetic mechanisms that include histone modifications, DNA methylation, and non-coding RNA-mediated gene silencing are often deregulated in a variety of cancers. Subnuclear localization of key proteins in the interphase nucleus and bookmarking of genes by lineage commitment factors in mitosis-a new dimension to epigenetic control of fundamental biological processes-is also modified in cancer. In this review, we discuss the various aspects of epigenetic control that are operative in a variety of cancers and their potential for risk assessment, early detection, targeted therapy, and personalized medicine.

Original languageEnglish (US)
Pages (from-to)2103-2108
Number of pages6
JournalJournal of Cellular Physiology
Volume228
Issue number11
DOIs
StatePublished - Nov 2013

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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    Zaidi, S. K., Van Wijnen, A. J., Lian, J. B., Stein, J. L., & Stein, G. S. (2013). Targeting deregulated epigenetic control in cancer. Journal of Cellular Physiology, 228(11), 2103-2108. https://doi.org/10.1002/jcp.24387