Targeting deregulated epigenetic control in cancer

Sayyed K. Zaidi, Andre J van Wijnen, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cancer is a multifaceted disease that involves acquisition of genetic mutations, deletions, and amplifications as well as deregulation of epigenetic mechanisms that fine-tune gene regulation. Key epigenetic mechanisms that include histone modifications, DNA methylation, and non-coding RNA-mediated gene silencing are often deregulated in a variety of cancers. Subnuclear localization of key proteins in the interphase nucleus and bookmarking of genes by lineage commitment factors in mitosis-a new dimension to epigenetic control of fundamental biological processes-is also modified in cancer. In this review, we discuss the various aspects of epigenetic control that are operative in a variety of cancers and their potential for risk assessment, early detection, targeted therapy, and personalized medicine.

Original languageEnglish (US)
Pages (from-to)2103-2108
Number of pages6
JournalJournal of Cellular Physiology
Volume228
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Epigenomics
Genes
Untranslated RNA
Deregulation
Gene expression
Risk assessment
Histones
Medicine
Amplification
Neoplasms
Histone Code
Biological Phenomena
Precision Medicine
Sequence Deletion
Interphase
Gene Silencing
DNA Methylation
Mitosis
Proteins
Therapeutics

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Zaidi, S. K., van Wijnen, A. J., Lian, J. B., Stein, J. L., & Stein, G. S. (2013). Targeting deregulated epigenetic control in cancer. Journal of Cellular Physiology, 228(11), 2103-2108. https://doi.org/10.1002/jcp.24387

Targeting deregulated epigenetic control in cancer. / Zaidi, Sayyed K.; van Wijnen, Andre J; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.

In: Journal of Cellular Physiology, Vol. 228, No. 11, 11.2013, p. 2103-2108.

Research output: Contribution to journalArticle

Zaidi, SK, van Wijnen, AJ, Lian, JB, Stein, JL & Stein, GS 2013, 'Targeting deregulated epigenetic control in cancer', Journal of Cellular Physiology, vol. 228, no. 11, pp. 2103-2108. https://doi.org/10.1002/jcp.24387
Zaidi SK, van Wijnen AJ, Lian JB, Stein JL, Stein GS. Targeting deregulated epigenetic control in cancer. Journal of Cellular Physiology. 2013 Nov;228(11):2103-2108. https://doi.org/10.1002/jcp.24387
Zaidi, Sayyed K. ; van Wijnen, Andre J ; Lian, Jane B. ; Stein, Janet L. ; Stein, Gary S. / Targeting deregulated epigenetic control in cancer. In: Journal of Cellular Physiology. 2013 ; Vol. 228, No. 11. pp. 2103-2108.
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