Targeting B Lymphocytes as Therapy for ANCA-Associated Vasculitis

Jason M. Golbin, Ulrich Specks

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

This article focuses on the initial results achieved with the more selective immunosuppressive approach of B-lymphocyte depletion in patients who fail cyclophosphamide or have contraindications for its use in the treatment of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This novel approach has sparked hope for patients and physicians in their search for effective, well-tolerated therapy for AAV. B-cell depletion is now undergoing rigorous investigation in randomized clinical trials.

Original languageEnglish (US)
Pages (from-to)741-754
Number of pages14
JournalRheumatic Disease Clinics of North America
Volume33
Issue number4
DOIs
StatePublished - Nov 1 2007

ASJC Scopus subject areas

  • Rheumatology

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