Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium

Ali Jalali, E. Susan Amirian, Matthew N. Bainbridge, Georgina N. Armstrong, Yanhong Liu, Spyros Tsavachidis, Shalini N. Jhangiani, Sharon E. Plon, Ching C. Lau, Elizabeth B. Claus, Jill S. Barnholtz-Sloan, Dora Il'yasova, Joellen Schildkraut, Francis Ali-Osman, Siegal Sadetzki, Christoffer Johansen, Richard S. Houlston, Robert Brian Jenkins, Daniel H Lachance, Sara H. OlsonJonine L. Bernstein, Ryan T. Merrell, Margaret R. Wrensch, Faith G. Davis, Rose Lai, Sanjay Shete, Kenneth Aldape, Christopher I. Amos, Donna M. Muzny, Richard A. Gibbs, Beatrice S. Melin, Melissa L. Bondy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant linkage peaks on chromosome 17q. Here, we use data from next generation and Sanger sequencing to identify familial glioma candidate genes and variants on chromosome 17q for further investigation. We applied a filtering schema to narrow the original list of 4830 annotated variants down to 21 very rare (

Original languageEnglish (US)
Article number8278
JournalScientific Reports
Volume5
DOIs
StatePublished - Feb 5 2015

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Glioma
Chromosomes
Brain Neoplasms
Genes
Neoplasms

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Jalali, A., Amirian, E. S., Bainbridge, M. N., Armstrong, G. N., Liu, Y., Tsavachidis, S., ... Bondy, M. L. (2015). Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium. Scientific Reports, 5, [8278]. https://doi.org/10.1038/srep08278

Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium. / Jalali, Ali; Amirian, E. Susan; Bainbridge, Matthew N.; Armstrong, Georgina N.; Liu, Yanhong; Tsavachidis, Spyros; Jhangiani, Shalini N.; Plon, Sharon E.; Lau, Ching C.; Claus, Elizabeth B.; Barnholtz-Sloan, Jill S.; Il'yasova, Dora; Schildkraut, Joellen; Ali-Osman, Francis; Sadetzki, Siegal; Johansen, Christoffer; Houlston, Richard S.; Jenkins, Robert Brian; Lachance, Daniel H; Olson, Sara H.; Bernstein, Jonine L.; Merrell, Ryan T.; Wrensch, Margaret R.; Davis, Faith G.; Lai, Rose; Shete, Sanjay; Aldape, Kenneth; Amos, Christopher I.; Muzny, Donna M.; Gibbs, Richard A.; Melin, Beatrice S.; Bondy, Melissa L.

In: Scientific Reports, Vol. 5, 8278, 05.02.2015.

Research output: Contribution to journalArticle

Jalali, A, Amirian, ES, Bainbridge, MN, Armstrong, GN, Liu, Y, Tsavachidis, S, Jhangiani, SN, Plon, SE, Lau, CC, Claus, EB, Barnholtz-Sloan, JS, Il'yasova, D, Schildkraut, J, Ali-Osman, F, Sadetzki, S, Johansen, C, Houlston, RS, Jenkins, RB, Lachance, DH, Olson, SH, Bernstein, JL, Merrell, RT, Wrensch, MR, Davis, FG, Lai, R, Shete, S, Aldape, K, Amos, CI, Muzny, DM, Gibbs, RA, Melin, BS & Bondy, ML 2015, 'Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium', Scientific Reports, vol. 5, 8278. https://doi.org/10.1038/srep08278
Jalali, Ali ; Amirian, E. Susan ; Bainbridge, Matthew N. ; Armstrong, Georgina N. ; Liu, Yanhong ; Tsavachidis, Spyros ; Jhangiani, Shalini N. ; Plon, Sharon E. ; Lau, Ching C. ; Claus, Elizabeth B. ; Barnholtz-Sloan, Jill S. ; Il'yasova, Dora ; Schildkraut, Joellen ; Ali-Osman, Francis ; Sadetzki, Siegal ; Johansen, Christoffer ; Houlston, Richard S. ; Jenkins, Robert Brian ; Lachance, Daniel H ; Olson, Sara H. ; Bernstein, Jonine L. ; Merrell, Ryan T. ; Wrensch, Margaret R. ; Davis, Faith G. ; Lai, Rose ; Shete, Sanjay ; Aldape, Kenneth ; Amos, Christopher I. ; Muzny, Donna M. ; Gibbs, Richard A. ; Melin, Beatrice S. ; Bondy, Melissa L. / Targeted Sequencing in Chromosome 17q Linkage Region Identifies Familial Glioma Candidates in the Gliogene Consortium. In: Scientific Reports. 2015 ; Vol. 5.
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AU - Armstrong, Georgina N.

AU - Liu, Yanhong

AU - Tsavachidis, Spyros

AU - Jhangiani, Shalini N.

AU - Plon, Sharon E.

AU - Lau, Ching C.

AU - Claus, Elizabeth B.

AU - Barnholtz-Sloan, Jill S.

AU - Il'yasova, Dora

AU - Schildkraut, Joellen

AU - Ali-Osman, Francis

AU - Sadetzki, Siegal

AU - Johansen, Christoffer

AU - Houlston, Richard S.

AU - Jenkins, Robert Brian

AU - Lachance, Daniel H

AU - Olson, Sara H.

AU - Bernstein, Jonine L.

AU - Merrell, Ryan T.

AU - Wrensch, Margaret R.

AU - Davis, Faith G.

AU - Lai, Rose

AU - Shete, Sanjay

AU - Aldape, Kenneth

AU - Amos, Christopher I.

AU - Muzny, Donna M.

AU - Gibbs, Richard A.

AU - Melin, Beatrice S.

AU - Bondy, Melissa L.

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