TY - JOUR
T1 - Targeted entry of enveloped viruses
T2 - Measles and herpes simplex virus i
AU - Navaratnarajah, Chanakha K.
AU - Miest, Tanner S.
AU - Carfi, Andrea
AU - Cattaneo, Roberto
N1 - Funding Information:
The authors would like to thank Ethan C. Settembre for help with Figure 2 . RC was funded by National Institutes of Health R01 CA90636 and R01 CA139389.
PY - 2012/2
Y1 - 2012/2
N2 - We compare the receptor-based mechanisms that a small RNA virus and a larger DNA virus have evolved to drive the fusion of viral and cellular membranes. Both systems rely on tight control over triggering the concerted refolding of a trimeric fusion protein. While measles virus entry depends on a receptor-binding protein and a fusion protein only, the herpes simplex virus (HSV) is more complex and requires four viral proteins. Nevertheless, in both viruses a receptor-binding protein is required for triggering the membrane fusion process. Moreover, specificity domains can be appended to these receptor-binding proteins to target virus entry to cells expressing a designated receptor. We discuss how principles established with measles and HSV can be applied to targeting other enveloped viruses, and alternatively how retargeted envelopes can be fitted on foreign capsids.
AB - We compare the receptor-based mechanisms that a small RNA virus and a larger DNA virus have evolved to drive the fusion of viral and cellular membranes. Both systems rely on tight control over triggering the concerted refolding of a trimeric fusion protein. While measles virus entry depends on a receptor-binding protein and a fusion protein only, the herpes simplex virus (HSV) is more complex and requires four viral proteins. Nevertheless, in both viruses a receptor-binding protein is required for triggering the membrane fusion process. Moreover, specificity domains can be appended to these receptor-binding proteins to target virus entry to cells expressing a designated receptor. We discuss how principles established with measles and HSV can be applied to targeting other enveloped viruses, and alternatively how retargeted envelopes can be fitted on foreign capsids.
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U2 - 10.1016/j.coviro.2011.12.002
DO - 10.1016/j.coviro.2011.12.002
M3 - Review article
C2 - 22440965
AN - SCOPUS:84857364081
SN - 1879-6257
VL - 2
SP - 43
EP - 49
JO - Current Opinion in Virology
JF - Current Opinion in Virology
IS - 1
ER -