Targeted entry of enveloped viruses: Measles and herpes simplex virus i

Chanakha K. Navaratnarajah, Tanner S. Miest, Andrea Carfi, Roberto Cattaneo

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

We compare the receptor-based mechanisms that a small RNA virus and a larger DNA virus have evolved to drive the fusion of viral and cellular membranes. Both systems rely on tight control over triggering the concerted refolding of a trimeric fusion protein. While measles virus entry depends on a receptor-binding protein and a fusion protein only, the herpes simplex virus (HSV) is more complex and requires four viral proteins. Nevertheless, in both viruses a receptor-binding protein is required for triggering the membrane fusion process. Moreover, specificity domains can be appended to these receptor-binding proteins to target virus entry to cells expressing a designated receptor. We discuss how principles established with measles and HSV can be applied to targeting other enveloped viruses, and alternatively how retargeted envelopes can be fitted on foreign capsids.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalCurrent Opinion in Virology
Volume2
Issue number1
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Virology

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