Targeted disruption of the pregnancy-associated plasma protein-A gene is associated with diminished smooth muscle cell response to insulin-like growth factor-I and resistance to neointimal hyperplasia after vascular injury

Medicine & Life Sciences

• Resistance To Insulin-Like Growth Factor I 100%
• Pregnancy-Associated Plasma Protein-A 74%
• Vascular System Injuries 57%
• Hyperplasia 45%
• Smooth Muscle Myocytes 45%
• Insulin-Like Growth Factor Binding Protein 4 42%
• Insulin-Like Growth Factor I 24%
• Genes 20%
• Vascular Smooth Muscle 11%
• Wounds and Injuries 7%
• Ligation 6%
• Peptide Hydrolases 6%
• Insulin-Like Growth Factor Binding Protein 5 6%
• Neointima 5%
• IGF Type 1 Receptor 5%
• Blood Vessels 4%
• Proliferating Cell Nuclear Antigen 4%
• Metalloproteases 4%
• Proteolysis 3%
• Staining and Labeling 2%
• Messenger RNA 2%
• In Vitro Techniques 1%