Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

Jinzhou Huang, Qin Zhou, Ming Gao, Somaira Nowsheen, Fei Zhao, Wootae Kim, Qian Zhu, Yusuke Kojima, Ping Yin, Yong Zhang, Guijie Guo, Xinyi Tu, Min Deng, Kuntian Luo, Bo Qin, Yuichi Machida, Zhenkun Lou

Research output: Contribution to journalArticle

Abstract

Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitination followed by acetylation. This way, cells can keep SPRTN activity in check, thereby promoting DPC repair, genomic stability, and healthy aging.

Original languageEnglish (US)
Pages (from-to)824-835.e5
JournalMolecular Cell
Volume79
Issue number5
DOIs
StatePublished - Sep 3 2020

Keywords

  • DNA repair
  • DNA-protein crosslink
  • SPRTN
  • Top1cc
  • VCPIP1/VCIP135
  • acetylation
  • aging
  • genomic instability
  • metalloprotease
  • ubiquitination

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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  • Cite this

    Huang, J., Zhou, Q., Gao, M., Nowsheen, S., Zhao, F., Kim, W., Zhu, Q., Kojima, Y., Yin, P., Zhang, Y., Guo, G., Tu, X., Deng, M., Luo, K., Qin, B., Machida, Y., & Lou, Z. (2020). Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Molecular Cell, 79(5), 824-835.e5. https://doi.org/10.1016/j.molcel.2020.06.027