Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

Jinzhou Huang; Qin Zhou; Ming Gao; Somaira Nowsheen; Fei Zhao; Wootae Kim; Qian Zhu; Yusuke Kojima; Ping Yin; Yong Zhang; Guijie Guo; Xinyi Tu; Min Deng; Kuntian Luo; Bo Qin; Yuichi Machida; Zhenkun Lou

doi:10.1016/j.molcel.2020.06.027

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

Jinzhou Huang, Qin Zhou, Ming Gao, Somaira Nowsheen, Fei Zhao, Wootae Kim, Qian Zhu, Yusuke Kojima, Ping Yin, Yong Zhang, Guijie Guo, Xinyi Tu, Min Deng, Kuntian Luo, Bo Qin, Yuichi Machida, Zhenkun Lou

Oncology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitination followed by acetylation. This way, cells can keep SPRTN activity in check, thereby promoting DPC repair, genomic stability, and healthy aging.

Original language	English (US)
Pages (from-to)	824-835.e5
Journal	Molecular Cell
Volume	79
Issue number	5
DOIs	https://doi.org/10.1016/j.molcel.2020.06.027
State	Published - Sep 3 2020

Keywords

DNA repair
DNA-protein crosslink
SPRTN
Top1cc
VCPIP1/VCIP135
acetylation
aging
genomic instability
metalloprotease
ubiquitination

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.06.027

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Huang, J., Zhou, Q., Gao, M., Nowsheen, S., Zhao, F., Kim, W., Zhu, Q., Kojima, Y., Yin, P., Zhang, Y., Guo, G., Tu, X., Deng, M., Luo, K., Qin, B., Machida, Y., & Lou, Z. (2020). Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Molecular Cell, 79(5), 824-835.e5. https://doi.org/10.1016/j.molcel.2020.06.027

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abstract = "Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitination followed by acetylation. This way, cells can keep SPRTN activity in check, thereby promoting DPC repair, genomic stability, and healthy aging.",

keywords = "DNA repair, DNA-protein crosslink, SPRTN, Top1cc, VCPIP1/VCIP135, acetylation, aging, genomic instability, metalloprotease, ubiquitination",

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T1 - Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

AU - Huang, Jinzhou

AU - Zhou, Qin

AU - Gao, Ming

AU - Nowsheen, Somaira

AU - Zhao, Fei

AU - Kim, Wootae

AU - Zhu, Qian

AU - Kojima, Yusuke

AU - Yin, Ping

AU - Zhang, Yong

AU - Guo, Guijie

AU - Tu, Xinyi

AU - Deng, Min

AU - Luo, Kuntian

AU - Qin, Bo

AU - Machida, Yuichi

AU - Lou, Zhenkun

PY - 2020/9/3

Y1 - 2020/9/3

N2 - Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitination followed by acetylation. This way, cells can keep SPRTN activity in check, thereby promoting DPC repair, genomic stability, and healthy aging.

AB - Huang et al. discover the deubiquitinase VCPIP1 is required for SPRTN activation and further demonstrate that SPRTN activation is regulated by two-step post-translational modification, deubiquitination followed by acetylation. This way, cells can keep SPRTN activity in check, thereby promoting DPC repair, genomic stability, and healthy aging.

KW - DNA repair

KW - DNA-protein crosslink

KW - SPRTN

KW - Top1cc

KW - VCPIP1/VCIP135

KW - acetylation

KW - aging

KW - genomic instability

KW - metalloprotease

KW - ubiquitination

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SN - 1097-2765

VL - 79

SP - 824-835.e5

JO - Molecular Cell

JF - Molecular Cell

IS - 5

ER -

Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

Abstract

Keywords

ASJC Scopus subject areas

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