Tamoxifen: Using pharmacogenetics to rediscover an old drug

Research output: Contribution to journalArticle

Abstract

Tamoxifen can be considered a classic 'pro-drug', requiring metabolic activation to elicit pharmacological activity. Our findings suggest that both genetic and drug-induced factors that alter CYP2D6 enzyme activity influence the clinical response to tamoxifen. Given the small differences in disease-free survival comparing tamoxifen to third-generation aromatase inhibitors, knowledge of the genetic and environmental factors that influence CYP2D6 enzyme activity may provide a robust tool to individualize the hormonal therapy to breast cancer.

Original languageEnglish (US)
Article numbere20
JournalBreast Cancer Online
Volume10
Issue number10
DOIs
StatePublished - Oct 2007

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Keywords

  • Aromatase inhibitors
  • Breast cancer
  • Endocrine therapy
  • Estrogen receptor
  • Tamoxifen

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)
  • Cancer Research

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