TY - JOUR
T1 - Talkativeness in cognitively normal women at genetic risk for Alzheimer's disease
AU - Newman, M. C.
AU - Holland, A. L.
AU - Caselli, R. J.
AU - Gongoll, R.
AU - White, K.
AU - Reiman, E. M.
N1 - Funding Information:
* This work was supported by a National Research Service Award, National Institute on Aging (NIA) Grant #1F32AG05803-01 (Mary C. Newman); the National Multipurpose Research and Training Center, Grant DC-01409, from the National Institute on Deafness and Other Communication Disorders (postdoctoral fellowship for Mary C. Newman); National Institutes of Mental Health (NIMH) Grant #1 RO1 MH57899-01A1 (Eric M. Reiman); and a University of Arizona Small Grant (Mary C. Newman). Special thanks are extended to Michael Gottfried for his assistance in the planning of the language analyses. The authors also wish to thank Carolyn J. Barbieri for her invaluable assistance in the project, and to the participants who gave so generously of their time. Address correspondence to: Mary C. Newman, Department of Psychology, Southwest Missouri State University, Springfield, Missouri 65804, USA. Tel.: 417 836-6530. E-mail: mcn738f@smsu.edu Accepted for publication: June 21, 2000.
PY - 2000
Y1 - 2000
N2 - Previous research has suggested a correlation between some linguistic patterns and the risk for Alzheimer's disease (AD). There is increasing clinical need to identify factors that can be used alone or in combination to predict the onset of AD. The purpose of the present study was to explore the association of language skills and genetic risk for Alzheimer's disease. Oral and written language samples of cognitively normal women with a susceptibility gene for AD (ApoE ε4) were compared to those of noncarriers on measures of grammatical complexity, topic relevance, and talkativeness by observers unaware of participant genotypes. Participants included 29 ApoE ε4 carriers 49-73 years of age, and 29 ε4 noncarriers 48-76 years of age, most of whom had a first-degree relative with AD. Carriers and noncarriers were group matched for age, educational level, and estimated IQ. Participant groups did not differ significantly in language complexity or topic relevance. However, the ApoE ε4 group was significantly more talkative than the noncarrier group (p < .05).
AB - Previous research has suggested a correlation between some linguistic patterns and the risk for Alzheimer's disease (AD). There is increasing clinical need to identify factors that can be used alone or in combination to predict the onset of AD. The purpose of the present study was to explore the association of language skills and genetic risk for Alzheimer's disease. Oral and written language samples of cognitively normal women with a susceptibility gene for AD (ApoE ε4) were compared to those of noncarriers on measures of grammatical complexity, topic relevance, and talkativeness by observers unaware of participant genotypes. Participants included 29 ApoE ε4 carriers 49-73 years of age, and 29 ε4 noncarriers 48-76 years of age, most of whom had a first-degree relative with AD. Carriers and noncarriers were group matched for age, educational level, and estimated IQ. Participant groups did not differ significantly in language complexity or topic relevance. However, the ApoE ε4 group was significantly more talkative than the noncarrier group (p < .05).
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U2 - 10.1076/anec.7.4.217.797
DO - 10.1076/anec.7.4.217.797
M3 - Article
AN - SCOPUS:0034487481
SN - 1382-5585
VL - 7
SP - 217
EP - 226
JO - Aging, Neuropsychology, and Cognition
JF - Aging, Neuropsychology, and Cognition
IS - 4
ER -