Tacrolimus dose requirement based on the CYP3A5 genotype in renal transplant patients

Lihui Qu, Yingying Lu, Meike Ying, Bingjue Li, Chunhua Weng, Zhoutao Xie, Ludan Liang, Chuan Lin, Xian Yang, Shi Feng, Yucheng Wang, Xiujin Shen, Qin Zhou, Ying Chen, Zhimin Chen, Jianyong Wu, Weiqiang Lin, Yi Shen, Jing Qin, Hang XuFeng Xu, Junwen Wang, Jianghua Chen, Hong Jiang, Hongfeng Huang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Tacrolimus (FK506) and cyclosporine A (CsA) are widely used to protect graft function after renal transplantation. The aim of the present study is to determine whether the single nucleotide polymorphism of CYP3A5 is a predictive index of FK506 dose requirement, and also the selection yardstick of FK506 or CsA treatment.We tested archival peripheral blood of 218 kidney recipients for CYP3A5 genotyping with PCR-SSP. Meanwhile, the dose of FK506 and CsA was recorded, blood concentration of the drugs was measured, and graft outcome was monitored.These results indicate that CYP3A5*AA/AG carriers need higher FK506 dose than CYP3A5*GG homozygote to achieve the target blood concentration. For CYP3A5*GG carriers, taking FK506 or CsA are both advisable. CYP3A5*AA/AG carriers preferred to CsA treatment depending on the graft outcomes and drug costs. CYP3A5 genotyping is a new approach to detecting FK506 dose requirement and a predictive index for the FK506 or CsA treatment selection in kidney recipients.

Original languageEnglish (US)
Pages (from-to)81285-81294
Number of pages10
JournalOncotarget
Volume8
Issue number46
DOIs
StatePublished - 2017

Keywords

  • Acute rejection
  • CYP3A5
  • FK506
  • Renal transplantation

ASJC Scopus subject areas

  • Oncology

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    Qu, L., Lu, Y., Ying, M., Li, B., Weng, C., Xie, Z., Liang, L., Lin, C., Yang, X., Feng, S., Wang, Y., Shen, X., Zhou, Q., Chen, Y., Chen, Z., Wu, J., Lin, W., Shen, Y., Qin, J., ... Huang, H. (2017). Tacrolimus dose requirement based on the CYP3A5 genotype in renal transplant patients. Oncotarget, 8(46), 81285-81294. https://doi.org/10.18632/oncotarget.18150