Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation - 4-Year experience at a moderate-volume center

Sena Jensen, Elizabeth Connor Jackson, Lena Riley, Sudhakar Reddy, Jens Goebel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation was pioneered at the University of Pittsburgh but is not broadly practiced at other centers. We present our 4-year experience with a modified Pittsburgh protocol at our own moderate-volume center. Seventeen pediatric kidney transplant recipients were treated with a tacrolimus-based immunosuppressive regimen involving steroid withdrawal over 6-12 post-transplant months in most cases and followed for up to 49 months. Patient and graft survival as well as graft function were excellent, and beneficial effects on several cardiovascular parameters were noted. Complications included fungal infections, glucose intolerance and post-transplant lymphoproliferative disease and were generally managed successfully. While awaiting longer-term follow-up data, we conclude that tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation is potentially beneficial and feasible even at centers managing a rather small number of recipients.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalPediatric Transplantation
Volume7
Issue number2
DOIs
StatePublished - Apr 1 2003

Keywords

  • Kidney
  • Pediatric
  • Steroid
  • Tacrolimus
  • Transplantation
  • Withdrawal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Fingerprint Dive into the research topics of 'Tacrolimus-based immunosuppression with steroid withdrawal in pediatric kidney transplantation - 4-Year experience at a moderate-volume center'. Together they form a unique fingerprint.

Cite this