Tackling the phosphoproteome: Tools and strategies

Dario E. Kalume, Henrik Molina, Akhilesh Pandey

Research output: Contribution to journalReview articlepeer-review

184 Scopus citations

Abstract

Characterization of post-translational modifications in proteins is one of the major tasks that is to be accomplished in the post-genomic era. Phosphorylation is a key reversible modification that regulates enzymatic activity, subcellular localization, complex formation and degradation of proteins. Rapid advances in mass spectrometry instrumentation coupled to the development of analytical methods over the past several years now allow us to investigate the phosphoproteome on a global scale.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume7
Issue number1
DOIs
StatePublished - Feb 2003

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

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