TACI and BAFF-R mediate isotype switching in B cells

Emanuela Castigli, Stephen A. Wilson, Sumi Scott, Fatma Dedeoglu, Shengli Xu, Kong Peng Lam, Richard J. Bram, Haifa Jabara, Raif S. Geha

Research output: Contribution to journalArticle

369 Scopus citations

Abstract

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of Experimental Medicine
Volume201
Issue number1
DOIs
StatePublished - Jan 3 2005

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Castigli, E., Wilson, S. A., Scott, S., Dedeoglu, F., Xu, S., Lam, K. P., Bram, R. J., Jabara, H., & Geha, R. S. (2005). TACI and BAFF-R mediate isotype switching in B cells. Journal of Experimental Medicine, 201(1), 35-39. https://doi.org/10.1084/jem.20032000