TY - JOUR
T1 - TACI and BAFF-R mediate isotype switching in B cells
AU - Castigli, Emanuela
AU - Wilson, Stephen A.
AU - Scott, Sumi
AU - Dedeoglu, Fatma
AU - Xu, Shengli
AU - Lam, Kong Peng
AU - Bram, Richard J.
AU - Jabara, Haifa
AU - Geha, Raif S.
PY - 2005/1/3
Y1 - 2005/1/3
N2 - The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.
AB - The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.
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U2 - 10.1084/jem.20032000
DO - 10.1084/jem.20032000
M3 - Article
C2 - 15630136
AN - SCOPUS:12344297875
SN - 0022-1007
VL - 201
SP - 35
EP - 39
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 1
ER -