TACI and BAFF-R mediate isotype switching in B cells

Emanuela Castigli, Stephen A. Wilson, Sumi Scott, Fatma Dedeoglu, Shengli Xu, Kong Peng Lam, Richard J Bram, Haifa Jabara, Raif S. Geha

Research output: Contribution to journalArticle

363 Citations (Scopus)

Abstract

The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce isotype switching in murine B cells to IgG1, IgA, and IgE. APRIL and BAFF each engage two receptors, transmembrane activator and calcium-modulator and cytophilin ligand interactor (TACI) and B cell maturation antigen (BCMA), on B cells. In addition, BAFF engages a third receptor on B cells, BAFF-R. To determine the role of these receptors in isotype switching, we examined B cells from mice deficient in TACI, BCMA, and BAFF-R. The results obtained indicate that both TACI and BAFF-R are able to transduce signals that result in isotype switching.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalJournal of Experimental Medicine
Volume201
Issue number1
DOIs
StatePublished - Jan 3 2005

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Immunoglobulin Class Switching
B-Lymphocytes
B-Cell Maturation Antigen
Aptitude
Immunoglobulin A
Immunoglobulin E
Tumor Necrosis Factor-alpha
Immunoglobulin G
Ligands
Calcium

ASJC Scopus subject areas

  • Immunology

Cite this

Castigli, E., Wilson, S. A., Scott, S., Dedeoglu, F., Xu, S., Lam, K. P., ... Geha, R. S. (2005). TACI and BAFF-R mediate isotype switching in B cells. Journal of Experimental Medicine, 201(1), 35-39. https://doi.org/10.1084/jem.20032000

TACI and BAFF-R mediate isotype switching in B cells. / Castigli, Emanuela; Wilson, Stephen A.; Scott, Sumi; Dedeoglu, Fatma; Xu, Shengli; Lam, Kong Peng; Bram, Richard J; Jabara, Haifa; Geha, Raif S.

In: Journal of Experimental Medicine, Vol. 201, No. 1, 03.01.2005, p. 35-39.

Research output: Contribution to journalArticle

Castigli, E, Wilson, SA, Scott, S, Dedeoglu, F, Xu, S, Lam, KP, Bram, RJ, Jabara, H & Geha, RS 2005, 'TACI and BAFF-R mediate isotype switching in B cells', Journal of Experimental Medicine, vol. 201, no. 1, pp. 35-39. https://doi.org/10.1084/jem.20032000
Castigli E, Wilson SA, Scott S, Dedeoglu F, Xu S, Lam KP et al. TACI and BAFF-R mediate isotype switching in B cells. Journal of Experimental Medicine. 2005 Jan 3;201(1):35-39. https://doi.org/10.1084/jem.20032000
Castigli, Emanuela ; Wilson, Stephen A. ; Scott, Sumi ; Dedeoglu, Fatma ; Xu, Shengli ; Lam, Kong Peng ; Bram, Richard J ; Jabara, Haifa ; Geha, Raif S. / TACI and BAFF-R mediate isotype switching in B cells. In: Journal of Experimental Medicine. 2005 ; Vol. 201, No. 1. pp. 35-39.
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