T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

Hongxiang Liu; Hongtao Ye; Agnes RuskoneFourmestraux; Daphne De Jong; Stefano Pileri; Christian Thiede; Anne Lavergne; Henk Boot; Giancarlo Caletti; Thomas Wündisch; Thierry Molina; Babs G. Taal; Sabattini Elena; Togliani Thomas; Pier Luigi Zinzani; Andreas Neubauer; Manfred Stolte; Rifat A. Hamoudi; Ahmet Dogan; Peter G. Isaacson; Ming Qing Du

doi:10.1053/gast.2002.33047

T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

Hongxiang Liu, Hongtao Ye, Agnes RuskoneFourmestraux, Daphne De Jong, Stefano Pileri, Christian Thiede, Anne Lavergne, Henk Boot, Giancarlo Caletti, Thomas Wündisch, Thierry Molina, Babs G. Taal, Sabattini Elena, Togliani Thomas, Pier Luigi Zinzani, Andreas Neubauer, Manfred Stolte, Rifat A. Hamoudi, Ahmet Dogan, Peter G. IsaacsonMing Qing Du

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

340 Scopus citations

Abstract

Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage I_Etumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage I_E, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage I_E. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage I_E, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.

Original language	English (US)
Pages (from-to)	1286-1294
Number of pages	9
Journal	Gastroenterology
Volume	122
Issue number	5
DOIs	https://doi.org/10.1053/gast.2002.33047
State	Published - 2002

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1053/gast.2002.33047

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Liu, H., Ye, H., RuskoneFourmestraux, A., De Jong, D., Pileri, S., Thiede, C., Lavergne, A., Boot, H., Caletti, G., Wündisch, T., Molina, T., Taal, B. G., Elena, S., Thomas, T., Zinzani, P. L., Neubauer, A., Stolte, M., Hamoudi, R. A., Dogan, A., ... Du, M. Q. (2002). T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. Gastroenterology, 122(5), 1286-1294. https://doi.org/10.1053/gast.2002.33047

Liu, H, Ye, H, RuskoneFourmestraux, A, De Jong, D, Pileri, S, Thiede, C, Lavergne, A, Boot, H, Caletti, G, Wündisch, T, Molina, T, Taal, BG, Elena, S, Thomas, T, Zinzani, PL, Neubauer, A, Stolte, M, Hamoudi, RA, Dogan, A, Isaacson, PG & Du, MQ 2002, 'T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication', Gastroenterology, vol. 122, no. 5, pp. 1286-1294. https://doi.org/10.1053/gast.2002.33047

@article{0766b78203044e7886a50aa96ef11424,

title = "T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication",

abstract = "Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IEtumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.",

author = "Hongxiang Liu and Hongtao Ye and Agnes RuskoneFourmestraux and {De Jong}, Daphne and Stefano Pileri and Christian Thiede and Anne Lavergne and Henk Boot and Giancarlo Caletti and Thomas W{\"u}ndisch and Thierry Molina and Taal, {Babs G.} and Sabattini Elena and Togliani Thomas and Zinzani, {Pier Luigi} and Andreas Neubauer and Manfred Stolte and Hamoudi, {Rifat A.} and Ahmet Dogan and Isaacson, {Peter G.} and Du, {Ming Qing}",

year = "2002",

doi = "10.1053/gast.2002.33047",

language = "English (US)",

volume = "122",

pages = "1286--1294",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "5",

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TY - JOUR

T1 - T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

AU - Liu, Hongxiang

AU - Ye, Hongtao

AU - RuskoneFourmestraux, Agnes

AU - De Jong, Daphne

AU - Pileri, Stefano

AU - Thiede, Christian

AU - Lavergne, Anne

AU - Boot, Henk

AU - Caletti, Giancarlo

AU - Wündisch, Thomas

AU - Molina, Thierry

AU - Taal, Babs G.

AU - Elena, Sabattini

AU - Thomas, Togliani

AU - Zinzani, Pier Luigi

AU - Neubauer, Andreas

AU - Stolte, Manfred

AU - Hamoudi, Rifat A.

AU - Dogan, Ahmet

AU - Isaacson, Peter G.

AU - Du, Ming Qing

PY - 2002

Y1 - 2002

N2 - Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IEtumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.

AB - Background & Aims: Eradication of Helicobacter pylori leads to cure of gastric mucosa-associated lymphoid tissue (MALT) lymphoma in 75% of localized cases. However, prolonged follow-up is necessary to determine whether a lymphoma responds to therapy. In a small series of cases, we showed that t(11;18)(q21;q21)-positive MALT lymphomas failed to respond to H. pylori eradication. The present study aimed to verify this finding in a large cohort and confirm whether the translocation predicts the response of stage IEtumors, for which clinical staging has little prognostic value. Methods: A total of 111 patients with H. pylori-positive gastric MALT lymphoma treated with antibiotics were studied. Clinical staging was undertaken before therapy. The response of lymphoma to H. pylori eradication was determined by histologic examination of gastric biopsy specimens. Diagnostic biopsy specimens were analyzed for t(11; 18)(q21;q21) by reverse-transcription polymerase chain reaction of the AP12-MALT1 transcript. Results: Forty-seven of the 48 patients who showed complete regression had lymphoma at stage IE, whereas 43 of the 63 nonresponsive cases were at stage IE and the remaining cases at stage IE, or above. t(11;18)(q21;q21) was detected in 2 of 48 complete-regression cases, and these positive cases showed relapse of lymphoma in the absence of H. pylori reinfection. In contrast, the translocation was present in 42 of the 63 nonresponsive cases, including 26 of 43 (60%) at stage IE. Conclusions: t(11; 18)(q21;q21)-positive gastric MALT lymphomas, including those at stage IE, do not respond to H. pylori eradication. Detection of the translocation should help the clinical management of patients with gastric MALT lymphoma.

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T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication

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