t 4 workshop report

Andre Kleensang, Alexandra Maertens, Michael Rosenberg, Suzanne Fitzpatrick, Justin Lamb, Scott Auerbach, Richard Brennan, Kevin M. Crofton, Ben Gordon, Albert J. Fornace, Kevin Gaido, David Gerhold, Robin Haw, Adriano Henney, Avi Ma'Ayan, Mary McBride, Stefano Monti, Michael F. Ochs, Akhilesh Pandey, Roded SharanRob Stierum, Stuart Tugendreich, Catherine Willett, Clemens Wittwehr, Jianguo Xia, Geoffrey W. Patton, Kirk Arvidson, Mounir Bouhifd, Helena T. Hogberg, Thomas Luechtefeld, Lena Smirnova, Liang Zhao, Yeyejide Adeleye, Minoru Kanehisa, Paul Carmichael, Melvin E. Andersen, Thomas Hartung

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Despite wide-spread consensus on the need to transform toxicology and risk assessment in order to keep pace with technological and computational changes that have revolutionized the life sciences, there remains much work to be done to achieve the vision of toxicology based on a mechanistic foundation. A workshop was organized to explore one key aspect of this transformation - the development of Pathways of Toxicity (PoT) as a key tool for hazard identification based on systems biology. Several issues were discussed in depth in the workshop: The first was the challenge of formally defining the concept of a PoT as distinct from, but complementary to, other toxicological pathway concepts such as mode of action (MoA). The workshop came up with a preliminary definition of PoT as "A molecular definition of cellular processes shown to mediate adverse outcomes of toxicants". It is further recognized that normal physiological pathways exist that maintain homeostasis and these, sufficiently perturbed, can become PoT. Second, the workshop sought to define the adequate public and commercial resources for PoT information, including data, visualization, analyses, tools, and use-cases, as well as the kinds of efforts that will be necessary to enable the creation of such a resource. Third, the workshop explored ways in which systems biology approaches could inform pathway annotation, and which resources are needed and available that can provide relevant PoT information to the diverse user communities.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalAltex
Volume31
Issue number1
DOIs
StatePublished - 2014

    Fingerprint

Keywords

  • Adverse outcome pathways
  • Human toxome
  • In vitro toxicology
  • Pathways of toxicity
  • Systems toxicology

ASJC Scopus subject areas

  • Pharmacology
  • Medical Laboratory Technology

Cite this

Kleensang, A., Maertens, A., Rosenberg, M., Fitzpatrick, S., Lamb, J., Auerbach, S., Brennan, R., Crofton, K. M., Gordon, B., Fornace, A. J., Gaido, K., Gerhold, D., Haw, R., Henney, A., Ma'Ayan, A., McBride, M., Monti, S., Ochs, M. F., Pandey, A., ... Hartung, T. (2014). t 4 workshop report Altex, 31(1), 53-61. https://doi.org/10.14573/altex.1309261