T-lymphocyte subsets in patients with idiopathic dilated cardiomyopathy

Kenneth C. Huber, Bernard J. Gersh, Declan D. Sugrue, Robert L. Frye, Kent R. Bailey, Roy E. Ritts

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

T-cell subsets were measured in the peripheral blood of 33 patients with heart failure from idiopathic dilated cardiomyopathy, 22 patients with heart failure from other causes, and 33 normal controls. Mean T-suppressor cell percentage was 30% in normals, 21% in patients with idiopathic dilated cardiomyopathy whose duration of symptoms was < 1 year (P = 0.005), and 26% in those with symptoms for > 1 year (P = 0.05). Similarly, percentage of T-suppressor cells in the group with heart failure from causes other than idiopathic dilated cardiomyopathy was significantly lower (23%; P = 0.005) in those with short duration of symptoms. When both heart failure groups were combined those with symptoms for < 1 year had significantly lower T-suppressor frequencies (22%) than those with symptoms for more than 1 year (P = 0.015). Multivariate analysis identified duration of symptoms and age as the only independent predictors of T-suppressor cell frequencies. Decreased percentage of T-suppressor cells in patients with idiopathic dilated cardiomyopathy may be an epiphenomenon related to duration of heart failure. This should be taken into account in assigning an etiologic mechanism for T-suppressor cells in idiopathic dilated cardiomyopathy.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalInternational Journal of Cardiology
Volume22
Issue number1
DOIs
StatePublished - Jan 1989

Keywords

  • Heart failure
  • Immunology

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'T-lymphocyte subsets in patients with idiopathic dilated cardiomyopathy'. Together they form a unique fingerprint.

Cite this