T lymphocyte response to H-2 mutants: Cytotoxic effectors are Ly-1 +2 +

P. J. Wettstein; D. W. Bailey; L. E. Mobraaten; J. Klein; J. A. Frelinger

doi:10.1073/pnas.76.7.3455

T lymphocyte response to H-2 mutants: Cytotoxic effectors are Ly-1 ⁺2 ⁺

P. J. Wettstein, D. W. Bailey, L. E. Mobraaten, J. Klein, J. A. Frelinger

Surgery Research

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Abstract

The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 ⁺2 ⁺. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 ⁺2 ⁺, demonstrated that Ly-1 ⁺2 ⁺ T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

Original language	English (US)
Pages (from-to)	3455-3459
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	76
Issue number	7
DOIs	https://doi.org/10.1073/pnas.76.7.3455
State	Published - 1979

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title = "T lymphocyte response to H-2 mutants: Cytotoxic effectors are Ly-1 +2 +",

abstract = "The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.",

author = "Wettstein, {P. J.} and Bailey, {D. W.} and Mobraaten, {L. E.} and J. Klein and Frelinger, {J. A.}",

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T1 - T lymphocyte response to H-2 mutants

T2 - Cytotoxic effectors are Ly-1 +2 +

AU - Wettstein, P. J.

AU - Bailey, D. W.

AU - Mobraaten, L. E.

AU - Klein, J.

AU - Frelinger, J. A.

PY - 1979

Y1 - 1979

N2 - The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

AB - The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2K(ba) and H-2D(da) alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement. Reconstitution analysis is demonstrated that the mutant-specific T cells were Ly-1 +2 +. These observations and those previously reported, which indicated that H-2K/D mutant-specific T cells proliferating in mixed lymphocyte culture were Ly-1 +2 +, demonstrated that Ly-1 +2 + T cells are immunocompetent. Furthermore, the nature of the stimulating H-2 complex alloantigen determines the Ly phenotype of response T cells.

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T lymphocyte response to H-2 mutants: Cytotoxic effectors are Ly-1 ⁺2 ⁺

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