T-cell subpopulations in chronic lymphocytic leukemia: Abnormalities in distribution and in in vitro receptor maturation

N. E. Kay, J. D. Johnson, R. Stanek, S. D. Douglas

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalBlood
Volume54
Issue number2
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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