T-cell subpopulations in chronic lymphocytic leukemia: Abnormalities in distribution and in in vitro receptor maturation

Neil Elliot Kay, J. D. Johnson, R. Stanek, S. D. Douglas

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.

Original languageEnglish (US)
Pages (from-to)540-544
Number of pages5
JournalBlood
Volume54
Issue number2
StatePublished - 1979
Externally publishedYes

Fingerprint

T-cells
B-Cell Chronic Lymphocytic Leukemia
T-Lymphocytes
T-Cell Antigen Receptor
Bearings (structural)
Immunoglobulin G
T-Cell Prolymphocytic Leukemia
IgG Receptors
Thymus
Cell membranes
Thymus Gland
Cell Membrane
Control Groups
Defects
In Vitro Techniques
immunoglobulin M receptor

ASJC Scopus subject areas

  • Hematology

Cite this

T-cell subpopulations in chronic lymphocytic leukemia : Abnormalities in distribution and in in vitro receptor maturation. / Kay, Neil Elliot; Johnson, J. D.; Stanek, R.; Douglas, S. D.

In: Blood, Vol. 54, No. 2, 1979, p. 540-544.

Research output: Contribution to journalArticle

@article{ae278ea674394eb39bec9d044ff35580,
title = "T-cell subpopulations in chronic lymphocytic leukemia: Abnormalities in distribution and in in vitro receptor maturation",
abstract = "Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.",
author = "Kay, {Neil Elliot} and Johnson, {J. D.} and R. Stanek and Douglas, {S. D.}",
year = "1979",
language = "English (US)",
volume = "54",
pages = "540--544",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "2",

}

TY - JOUR

T1 - T-cell subpopulations in chronic lymphocytic leukemia

T2 - Abnormalities in distribution and in in vitro receptor maturation

AU - Kay, Neil Elliot

AU - Johnson, J. D.

AU - Stanek, R.

AU - Douglas, S. D.

PY - 1979

Y1 - 1979

N2 - Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.

AB - Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.

UR - http://www.scopus.com/inward/record.url?scp=0018646157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018646157&partnerID=8YFLogxK

M3 - Article

C2 - 313223

AN - SCOPUS:0018646157

VL - 54

SP - 540

EP - 544

JO - Blood

JF - Blood

SN - 0006-4971

IS - 2

ER -