Abstract
Purified human thymus-derived (T) lymphocytes were analyzed by detection of Fc receptors for either IgG or IgM in healthy controls and in patients with chronic lymphocytic leukemia (CLL). There was a significant and persistent increase in the numbers of T cells bearing receptors for IgG (Fcγ) in CLL patients in comparison to the controls. After an in vitro culture period, there was a significantly decreased appearance of cells with IgM receptors (Fcμ) in CLL patients in comparison to the control group. These results indicate an imbalance in circulating T-cell subpopulations for CLL patients. In addition, an in vitro defect in CLL T-cell membrane receptor appearance is present.
Original language | English (US) |
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Pages (from-to) | 540-544 |
Number of pages | 5 |
Journal | Blood |
Volume | 54 |
Issue number | 2 |
DOIs | |
State | Published - 1979 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology