T-cell receptor gene rearrangement analysis: Cutaneous T cell lymphoma, peripheral T cell lymphoma, and premalignant and benign cutaneous lymphoproliferative disorders

Brian D. Zelickson, Margot S. Peters, Sigfrid A. Muller, Stephen N. Thibodeau, John A. Lust, Lynn M. Quam, Mark R. Pittelkow

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

T-cell receptor gene rearrangement analysis is a useful technique to detect clonality and determine lineage of lymphoid neoplasms. We examined 103 patients with mycosis fungoides, Sézary syndrome, peripheral T cell lymphoma, potentially malignant lymphoproliferative disorders including pre-Sézary syndrome, large plaque parapsoriasis, lymphomatoid papulosis and follicular mucinosis, and various benign inflammatory infiltrates. A clonal rearrangement was detected in skin samples in 20 of 24 patients with mycosis fungoides and in peripheral blood samples in 19 of 21 patients with Sézary syndrome. A clonal population was also detected in seven of eight cases classified as peripheral T cell lymphoma. The potentially malignant dermatoses tended to have clonal rearrangement, with the exception of large plaque parapsoriasis, and further follow-up is needed to correlate clonality with the disease course. These studies demonstrate the value of molecular genetics as an adjunct to morphology in the examination of patients with cutaneous lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume25
Issue number5
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Dermatology

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