T-cell receptor gene rearrangement analysis

Cutaneous T cell lymphoma, peripheral T cell lymphoma, and premalignant and benign cutaneous lymphoproliferative disorders

B. D. Zelickson, M. S. Peters, S. A. Muller, Stephen N Thibodeau, J. A. Lust, L. M. Quam, M. R. Pittelkow

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

T-cell receptor gene rearrangement analysis is a useful technique to detect clonality and determine lineage of lymphoid neoplasms. We examined 103 patients with mycosis fungoides, Sezary syndrome, peripheral T cell lymphoma, potentially malignant lymphoproliferative disorders including pre-Sezary syndrome, large plaque parapsoriasis, lymphomatoid papulosis and follicular mucinosis, and various benign inflammatory infiltrates. A clonal rearrangement was detected in skin samples in 20 of 24 patients with mycosis fungoides and in peripheral blood samples in 19 of 21 patients with Sezary syndrome. A clonal population was also detected in seven of eight cases classified as peripheral T cell lymphoma. The potentially malignant dermatoses tended to have clonal rearrangement, with the exception of large plaque parapsoriasis, and further follow-up is needed to correlate clonality with the disease course. These studies demonstrate the value of molecular genetics as an adjunct to morphology in the examination of patients with cutaneous lymphoproliferative disease.

Original languageEnglish (US)
Pages (from-to)787-796
Number of pages10
JournalJournal of the American Academy of Dermatology
Volume25
Issue number5 I
StatePublished - 1991

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T-Lymphocyte Gene Rearrangement
Peripheral T-Cell Lymphoma
T-Cell Receptor Genes
Cutaneous T-Cell Lymphoma
Lymphoproliferative Disorders
Sezary Syndrome
Parapsoriasis
Mycosis Fungoides
Skin
Skin Diseases
Follicular Mucinosis
Lymphomatoid Papulosis
Molecular Biology
Population
Neoplasms

ASJC Scopus subject areas

  • Dermatology

Cite this

T-cell receptor gene rearrangement analysis : Cutaneous T cell lymphoma, peripheral T cell lymphoma, and premalignant and benign cutaneous lymphoproliferative disorders. / Zelickson, B. D.; Peters, M. S.; Muller, S. A.; Thibodeau, Stephen N; Lust, J. A.; Quam, L. M.; Pittelkow, M. R.

In: Journal of the American Academy of Dermatology, Vol. 25, No. 5 I, 1991, p. 787-796.

Research output: Contribution to journalArticle

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AU - Lust, J. A.

AU - Quam, L. M.

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