T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

Vincent C. Ho, Erik R. Hansen, James T. Elder, Ole Baadsgaard, Gunhild L. Vejlsgaard, Curtis A. Hanson, Kevin D. Cooper

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.

Original languageEnglish (US)
Pages (from-to)354-360
Number of pages7
JournalClinical Immunology and Immunopathology
Volume54
Issue number3
DOIs
StatePublished - Mar 1990

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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