T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

Vincent C. Ho; Erik R. Hansen; James T. Elder; Ole Baadsgaard; Gunhild L. Vejlsgaard; Curtis A. Hanson; Kevin D. Cooper

doi:10.1016/0090-1229(90)90049-V

T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

Vincent C. Ho, Erik R. Hansen, James T. Elder, Ole Baadsgaard, Gunhild L. Vejlsgaard, Curtis A. Hanson, Kevin D. Cooper

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.

Original language	English (US)
Pages (from-to)	354-360
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	54
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(90)90049-V
State	Published - Mar 1990

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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@article{cb50ea0bdb874cbabe457b596bb4e778,

title = "T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding",

abstract = "T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.",

author = "Ho, {Vincent C.} and Hansen, {Erik R.} and Elder, {James T.} and Ole Baadsgaard and Vejlsgaard, {Gunhild L.} and Hanson, {Curtis A.} and Cooper, {Kevin D.}",

note = "Funding Information: {\textquoteright} This work was supported in part by NIH Grant ARO1770-02 (K.D.C.). Dr. Ho was a recipient of the R. S. McLaughlin Research Fellowship from Canada during this study. {\textquoteright} Currently affiliated with the Division of Dermatology, University of British Columbia, Vancouver, Canada.",

year = "1990",

month = mar,

doi = "10.1016/0090-1229(90)90049-V",

language = "English (US)",

volume = "54",

pages = "354--360",

journal = "Clinical Immunology",

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publisher = "Academic Press Inc.",

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TY - JOUR

T1 - T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma

T2 - An unusual finding

AU - Ho, Vincent C.

AU - Hansen, Erik R.

AU - Elder, James T.

AU - Baadsgaard, Ole

AU - Vejlsgaard, Gunhild L.

AU - Hanson, Curtis A.

AU - Cooper, Kevin D.

N1 - Funding Information: ’ This work was supported in part by NIH Grant ARO1770-02 (K.D.C.). Dr. Ho was a recipient of the R. S. McLaughlin Research Fellowship from Canada during this study. ’ Currently affiliated with the Division of Dermatology, University of British Columbia, Vancouver, Canada.

PY - 1990/3

Y1 - 1990/3

N2 - T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.

AB - T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.

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JO - Clinical Immunology

JF - Clinical Immunology

IS - 3

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T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

Abstract

ASJC Scopus subject areas

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