T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding

Vincent C. Ho, Erik R. Hansen, James T. Elder, Ole Baadsgaard, Gunhild L. Vejlsgaard, Curtis A. Hanson, Kevin D. Cooper

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor β-chain gene in the absence of rearrangement of the γ-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed.

Original languageEnglish (US)
Pages (from-to)354-360
Number of pages7
JournalClinical Immunology and Immunopathology
Volume54
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

T-Cell Receptor Genes
Cutaneous T-Cell Lymphoma
Gene Rearrangement
T-Lymphocytes
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma : An unusual finding. / Ho, Vincent C.; Hansen, Erik R.; Elder, James T.; Baadsgaard, Ole; Vejlsgaard, Gunhild L.; Hanson, Curtis A.; Cooper, Kevin D.

In: Clinical Immunology and Immunopathology, Vol. 54, No. 3, 1990, p. 354-360.

Research output: Contribution to journalArticle

Ho, Vincent C. ; Hansen, Erik R. ; Elder, James T. ; Baadsgaard, Ole ; Vejlsgaard, Gunhild L. ; Hanson, Curtis A. ; Cooper, Kevin D. / T cell receptor β-chain gene rearrangement without γ-chain gene rearrangement in cutaneous T cell lymphoma : An unusual finding. In: Clinical Immunology and Immunopathology. 1990 ; Vol. 54, No. 3. pp. 354-360.
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