T-cell-mediated antitumor immunity in B-cell non-Hodgkin lymphoma: Activation, suppression and exhaustion

Zhi Zhang Yang, Ai Bin Liang, Stephen M. Ansell

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

The tumor microenvironment in B-cell non-Hodgkin lymphoma (NHL) comprises not only malignant cells but also significant numbers of normal immune cells. The intratumoral immune infiltrate includes T-lymphocytes that appear to target the malignant clone. Despite immunologically recognizing the lymphoma cells, the intratumoral T-cells are unable to eradicate the malignant cells and the lymphoma commonly progresses. Recent data has identified mechanisms whereby activated intratumoral T-cells are suppressed or become exhausted due to chronic antigen stimulation. A clearer understanding of these mechanisms will allow for strategies to overcome them and improve the outcome of patients with lymphoma.

Original languageEnglish (US)
Pages (from-to)2498-2504
Number of pages7
JournalLeukemia and Lymphoma
Volume56
Issue number9
DOIs
StatePublished - Sep 2 2015

Keywords

  • Lymphoma
  • T cells
  • anti-tumour immunity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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