Abstract
The tumor microenvironment in B-cell non-Hodgkin lymphoma (NHL) comprises not only malignant cells but also significant numbers of normal immune cells. The intratumoral immune infiltrate includes T-lymphocytes that appear to target the malignant clone. Despite immunologically recognizing the lymphoma cells, the intratumoral T-cells are unable to eradicate the malignant cells and the lymphoma commonly progresses. Recent data has identified mechanisms whereby activated intratumoral T-cells are suppressed or become exhausted due to chronic antigen stimulation. A clearer understanding of these mechanisms will allow for strategies to overcome them and improve the outcome of patients with lymphoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2498-2504 |
| Number of pages | 7 |
| Journal | Leukemia and Lymphoma |
| Volume | 56 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2 2015 |
Keywords
- Lymphoma
- T cells
- anti-tumour immunity
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research