T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group

Tanu Goyal, Beenu Thakral, Sa A. Wang, Carlos E. Bueso-Ramos, Min Shi, Dragan Jevremovic, William G. Morice, Qian Yun Zhang, Tracy I. George, Kathryn K. Foucar, Siddharth Bhattacharyya, Adam Bagg, Heesun J. Rogers, Juraj Bodo, Lisa Durkin, Eric D. Hsi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).

Original languageEnglish (US)
Pages (from-to)164-171
Number of pages8
JournalAmerican journal of clinical pathology
Volume149
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • B-cell lymphoma
  • Diffuse large B-cell lymphoma
  • T-LGL leukemia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Goyal, T., Thakral, B., Wang, S. A., Bueso-Ramos, C. E., Shi, M., Jevremovic, D., Morice, W. G., Zhang, Q. Y., George, T. I., Foucar, K. K., Bhattacharyya, S., Bagg, A., Rogers, H. J., Bodo, J., Durkin, L., & Hsi, E. D. (2018). T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group. American journal of clinical pathology, 149(2), 164-171. https://doi.org/10.1093/AJCP/AQX146