T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group

Tanu Goyal; Beenu Thakral; Sa A. Wang; Carlos E. Bueso-Ramos; Min Shi; Dragan Jevremovic; William G. Morice; Qian Yun Zhang; Tracy I. George; Kathryn K. Foucar; Siddharth Bhattacharyya; Adam Bagg; Heesun J. Rogers; Juraj Bodo; Lisa Durkin; Eric D. Hsi

doi:10.1093/AJCP/AQX146

T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group

Tanu Goyal, Beenu Thakral, Sa A. Wang, Carlos E. Bueso-Ramos, Min Shi, Dragan Jevremovic, William G. Morice, Qian Yun Zhang, Tracy I. George, Kathryn K. Foucar, Siddharth Bhattacharyya, Adam Bagg, Heesun J. Rogers, Juraj Bodo, Lisa Durkin, Eric D. Hsi

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).

Original language	English (US)
Pages (from-to)	164-171
Number of pages	8
Journal	American journal of clinical pathology
Volume	149
Issue number	2
DOIs	https://doi.org/10.1093/AJCP/AQX146
State	Published - Feb 1 2018

Keywords

B-cell lymphoma
Diffuse large B-cell lymphoma
T-LGL leukemia

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1093/AJCP/AQX146

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Goyal, T., Thakral, B., Wang, S. A., Bueso-Ramos, C. E., Shi, M., Jevremovic, D., Morice, W. G., Zhang, Q. Y., George, T. I., Foucar, K. K., Bhattacharyya, S., Bagg, A., Rogers, H. J., Bodo, J., Durkin, L., & Hsi, E. D. (2018). T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group. American journal of clinical pathology, 149(2), 164-171. https://doi.org/10.1093/AJCP/AQX146

Goyal, T, Thakral, B, Wang, SA, Bueso-Ramos, CE, Shi, M, Jevremovic, D, Morice, WG, Zhang, QY, George, TI, Foucar, KK, Bhattacharyya, S, Bagg, A, Rogers, HJ, Bodo, J, Durkin, L & Hsi, ED 2018, 'T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group', American journal of clinical pathology, vol. 149, no. 2, pp. 164-171. https://doi.org/10.1093/AJCP/AQX146

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title = "T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group",

abstract = "Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).",

keywords = "B-cell lymphoma, Diffuse large B-cell lymphoma, T-LGL leukemia",

author = "Tanu Goyal and Beenu Thakral and Wang, {Sa A.} and Bueso-Ramos, {Carlos E.} and Min Shi and Dragan Jevremovic and Morice, {William G.} and Zhang, {Qian Yun} and George, {Tracy I.} and Foucar, {Kathryn K.} and Siddharth Bhattacharyya and Adam Bagg and Rogers, {Heesun J.} and Juraj Bodo and Lisa Durkin and Hsi, {Eric D.}",

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doi = "10.1093/AJCP/AQX146",

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AU - Thakral, Beenu

AU - Wang, Sa A.

AU - Bueso-Ramos, Carlos E.

AU - Shi, Min

AU - Jevremovic, Dragan

AU - Morice, William G.

AU - Zhang, Qian Yun

AU - George, Tracy I.

AU - Foucar, Kathryn K.

AU - Bhattacharyya, Siddharth

AU - Bagg, Adam

AU - Rogers, Heesun J.

AU - Bodo, Juraj

AU - Durkin, Lisa

AU - Hsi, Eric D.

PY - 2018/2/1

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N2 - Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).

AB - Objective: T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods: We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results: Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion: To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).

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KW - Diffuse large B-cell lymphoma

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T-cell large granular lymphocytic leukemia and coexisting B-cell lymphomas: A study from the bone marrow pathology group

Abstract

Keywords

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