T cell division and death are segregated by mutation of TCRβ chain constant domains

Emma Teixeiro, Mark A. Daniels, Barbara Hausmann, Adam G. Schrum, Dieter Naeher, Immanuel Luescher, Margot Thome, Rafael Bragado, Ed Palmer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

We have studied the role of the T cell receptor (TCR) β chain transmembrane and cytoplasmic domains (βTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and βTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-κB. This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These β chain domains are involved in discriminating cell division and apoptosis.

Original languageEnglish (US)
Pages (from-to)515-526
Number of pages12
JournalImmunity
Volume21
Issue number4
DOIs
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Teixeiro, E., Daniels, M. A., Hausmann, B., Schrum, A. G., Naeher, D., Luescher, I., Thome, M., Bragado, R., & Palmer, E. (2004). T cell division and death are segregated by mutation of TCRβ chain constant domains. Immunity, 21(4), 515-526. https://doi.org/10.1016/j.immuni.2004.08.014