@article{415aaf05aba94b268427e6e2d05f3cec,
title = "T cell division and death are segregated by mutation of TCRβ chain constant domains",
abstract = "We have studied the role of the T cell receptor (TCR) β chain transmembrane and cytoplasmic domains (βTM/Cyto) in T cell signaling. Upon antigen stimulation, T lymphocytes expressing a TCR with mutant and βTM and Cyto domains accumulate in large numbers and are specifically defective in undergoing activation-induced cell death (AICD). The mutant TCR poorly recruits the protein adaptor Carma-1 and is subsequently impaired in activating NF-κB. This signaling defect leads to a reduced expression of Fas ligand (FasL) and to a reduction in AICD. These β chain domains are involved in discriminating cell division and apoptosis.",
author = "Emma Teixeiro and Daniels, {Mark A.} and Barbara Hausmann and Schrum, {Adam G.} and Dieter Naeher and Immanuel Luescher and Margot Thome and Rafael Bragado and Ed Palmer",
note = "Funding Information: This work was supported by fellowships from the Fundaci{\'o}n Ram{\'o}n Areces, Madrid, Spain (E.T.), The Cancer Research Institute, USA (M.A.D.), Ruth L. Kirschenstein National Research Service Award from NCI and NIH (A.G.S.), and grants from the Swiss National Science Foundation, Hoffmann La Roche, Ltd., Novartis, AG, the Ministerio de Ciencia y Tecnolog{\'ı}a, BMC2002-02644 (R.B.), and from the Swiss Cancer League (OCS 01168-09-2001) (M.T.). We thank J. Sprent, T. B{\"a}ckstr{\"o}m, and H. von Boehmer for interesting discussions; S. Stotz for generating the βTM/Cyto; U. M{\"u}ller for generating transgenic mice; S. Treves for assistance with the Ca 2+ flux; B. Favier for technical advice; and G. DeLibero, D. Gil, and G. Werlen for critical review of the manuscript. ",
year = "2004",
month = oct,
doi = "10.1016/j.immuni.2004.08.014",
language = "English (US)",
volume = "21",
pages = "515--526",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}