T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other

Timothy S. Gomez, Daniel D Billadeau

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

More than a quarter of a century has passed since the observation that T cells rapidly polarize their actin and microtubule cytoskeletal systems toward antigen-presenting cells during activation. Since this initial discovery, several receptors on T cells (e.g., T cell receptor [TCR], co-receptors, integrins, and chemokine receptors) have been identified to regulate these two cytoskeletal networks through complex signaling pathways, which are still being elucidated. There is now an undeniable body of biochemical, pharmacological, and genetic evidence indicating that regulators of actin and microtubule dynamics are crucial for T cell activation and effector functions. In fact, the actin cytoskeleton participates in the initial clustering of TCR-major histocompatability complex or peptide complexes, formation and stabilization of the immune synapse, integrin-mediated adhesion, and receptor sequestration, whereas both the actin and microtubule cytoskeletons regulate the establishment of cell polarity, cell migration, and directed secretion of cytokines and cytolytic granules. Over the past several years, we have begun to more thoroughly understand the contributions of specific actin-regulatory and actin-nucleating proteins that govern these processes. Herein, we discuss our current understanding of how activating receptors on T lymphocytes regulate the actin and microtubule cytoskeletons, and how in turn, these distinct but integrated cytoskeletal networks coordinate T cell immune responses.

Original languageEnglish (US)
Pages (from-to)1-64
Number of pages64
JournalAdvances in Immunology
Volume97
DOIs
StatePublished - 2008

Fingerprint

Cytoskeleton
Microtubules
Actins
T-Cell Antigen Receptor
Actin Cytoskeleton
T-Lymphocytes
Integrins
Cell Polarity
Chemokine Receptors
Antigen-Presenting Cells
Synapses
Cell Movement
Cluster Analysis
Molecular Biology
Pharmacology
Cytokines
Peptides
Proteins

ASJC Scopus subject areas

  • Immunology

Cite this

T Cell Activation and the Cytoskeleton : You Can't Have One Without the Other. / Gomez, Timothy S.; Billadeau, Daniel D.

In: Advances in Immunology, Vol. 97, 2008, p. 1-64.

Research output: Contribution to journalArticle

@article{48d9841344b8434aade0a3bd3126c169,
title = "T Cell Activation and the Cytoskeleton: You Can't Have One Without the Other",
abstract = "More than a quarter of a century has passed since the observation that T cells rapidly polarize their actin and microtubule cytoskeletal systems toward antigen-presenting cells during activation. Since this initial discovery, several receptors on T cells (e.g., T cell receptor [TCR], co-receptors, integrins, and chemokine receptors) have been identified to regulate these two cytoskeletal networks through complex signaling pathways, which are still being elucidated. There is now an undeniable body of biochemical, pharmacological, and genetic evidence indicating that regulators of actin and microtubule dynamics are crucial for T cell activation and effector functions. In fact, the actin cytoskeleton participates in the initial clustering of TCR-major histocompatability complex or peptide complexes, formation and stabilization of the immune synapse, integrin-mediated adhesion, and receptor sequestration, whereas both the actin and microtubule cytoskeletons regulate the establishment of cell polarity, cell migration, and directed secretion of cytokines and cytolytic granules. Over the past several years, we have begun to more thoroughly understand the contributions of specific actin-regulatory and actin-nucleating proteins that govern these processes. Herein, we discuss our current understanding of how activating receptors on T lymphocytes regulate the actin and microtubule cytoskeletons, and how in turn, these distinct but integrated cytoskeletal networks coordinate T cell immune responses.",
author = "Gomez, {Timothy S.} and Billadeau, {Daniel D}",
year = "2008",
doi = "10.1016/S0065-2776(08)00001-1",
language = "English (US)",
volume = "97",
pages = "1--64",
journal = "Advances in Immunology",
issn = "0065-2776",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - T Cell Activation and the Cytoskeleton

T2 - You Can't Have One Without the Other

AU - Gomez, Timothy S.

AU - Billadeau, Daniel D

PY - 2008

Y1 - 2008

N2 - More than a quarter of a century has passed since the observation that T cells rapidly polarize their actin and microtubule cytoskeletal systems toward antigen-presenting cells during activation. Since this initial discovery, several receptors on T cells (e.g., T cell receptor [TCR], co-receptors, integrins, and chemokine receptors) have been identified to regulate these two cytoskeletal networks through complex signaling pathways, which are still being elucidated. There is now an undeniable body of biochemical, pharmacological, and genetic evidence indicating that regulators of actin and microtubule dynamics are crucial for T cell activation and effector functions. In fact, the actin cytoskeleton participates in the initial clustering of TCR-major histocompatability complex or peptide complexes, formation and stabilization of the immune synapse, integrin-mediated adhesion, and receptor sequestration, whereas both the actin and microtubule cytoskeletons regulate the establishment of cell polarity, cell migration, and directed secretion of cytokines and cytolytic granules. Over the past several years, we have begun to more thoroughly understand the contributions of specific actin-regulatory and actin-nucleating proteins that govern these processes. Herein, we discuss our current understanding of how activating receptors on T lymphocytes regulate the actin and microtubule cytoskeletons, and how in turn, these distinct but integrated cytoskeletal networks coordinate T cell immune responses.

AB - More than a quarter of a century has passed since the observation that T cells rapidly polarize their actin and microtubule cytoskeletal systems toward antigen-presenting cells during activation. Since this initial discovery, several receptors on T cells (e.g., T cell receptor [TCR], co-receptors, integrins, and chemokine receptors) have been identified to regulate these two cytoskeletal networks through complex signaling pathways, which are still being elucidated. There is now an undeniable body of biochemical, pharmacological, and genetic evidence indicating that regulators of actin and microtubule dynamics are crucial for T cell activation and effector functions. In fact, the actin cytoskeleton participates in the initial clustering of TCR-major histocompatability complex or peptide complexes, formation and stabilization of the immune synapse, integrin-mediated adhesion, and receptor sequestration, whereas both the actin and microtubule cytoskeletons regulate the establishment of cell polarity, cell migration, and directed secretion of cytokines and cytolytic granules. Over the past several years, we have begun to more thoroughly understand the contributions of specific actin-regulatory and actin-nucleating proteins that govern these processes. Herein, we discuss our current understanding of how activating receptors on T lymphocytes regulate the actin and microtubule cytoskeletons, and how in turn, these distinct but integrated cytoskeletal networks coordinate T cell immune responses.

UR - http://www.scopus.com/inward/record.url?scp=44049096985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44049096985&partnerID=8YFLogxK

U2 - 10.1016/S0065-2776(08)00001-1

DO - 10.1016/S0065-2776(08)00001-1

M3 - Article

C2 - 18501768

AN - SCOPUS:44049096985

VL - 97

SP - 1

EP - 64

JO - Advances in Immunology

JF - Advances in Immunology

SN - 0065-2776

ER -