Systems biology of skeletal muscle: Fiber type as an organizing principle

Sarah M. Greising, Heather M. Gransee, Carlos B. Mantilla, Gary C. Sieck

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca2+ from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross-bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction.

Original languageEnglish (US)
Pages (from-to)457-473
Number of pages17
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume4
Issue number5
DOIs
StatePublished - Sep 2012

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Fingerprint Dive into the research topics of 'Systems biology of skeletal muscle: Fiber type as an organizing principle'. Together they form a unique fingerprint.

  • Cite this