TY - JOUR
T1 - Systems-based discovery advances drug development
AU - Waldman, S. A.
AU - Terzic, A.
PY - 2013/4
Y1 - 2013/4
N2 - Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery.
AB - Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery.
UR - http://www.scopus.com/inward/record.url?scp=84875471298&partnerID=8YFLogxK
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U2 - 10.1038/clpt.2013.21
DO - 10.1038/clpt.2013.21
M3 - Review article
C2 - 23511779
AN - SCOPUS:84875471298
SN - 0009-9236
VL - 93
SP - 285
EP - 287
JO - Clinical pharmacology and therapeutics
JF - Clinical pharmacology and therapeutics
IS - 4
ER -