Systems-based discovery advances drug development

S. A. Waldman, A. Terzic

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target-based activities of specific molecules in cell-free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target-based algorithms into comprehensive, systems-level approaches offering value-added strategies for optimized drug discovery.

Original languageEnglish (US)
Pages (from-to)285-287
Number of pages3
JournalClinical pharmacology and therapeutics
Volume93
Issue number4
DOIs
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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