Systemic vascular effects during acute rejection of lung allografts

Henrik Scherstén, Henry D. Tazelaar, Alexander R J Cale, Virginia M Miller, Christopher G A McGregor

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Circulating leukocytes activated during rejection of organ allografts could potentially have generalized effects on systemic blood vessels of the transplant recipient. Experiments were designed, therefore, to determine the function of the endothelium and smooth muscle of arteries from nontransplanted organs in dogs who received single lung transplants. Dogs underwent single lung allotransplantation and were immunosuppressed for 5 days. Immunosuppression was then withheld for 3 days, allowing rejection to occur. Dogs were studied at this time (rejecting) or following treatment for rejection for an additional 6-8 days (treated). Arteries from unoperated, untreated dogs also were studied to provide baseline responses of healthy tissue. Rings cut from left circumflex coronary, nonoperated native pulmonary, and renal arteries were suspended in organ chambers for measurement of isometric force. Endothelium-dependent relaxations to the calcium ionophore A23187 were not affected by rejection in any of the arteries. Contractions to angiotensin I were reduced significantly only in native pulmonary arteries. Contractions to KCl and endothelin-1 increased in renal arteries with endothelium during rejection. These contractions in renal arteries were reduced following treatment of rejection. None of the responses of the coronary arteries were affected significantly by rejection of the lung allograft. These results demonstrate that contractions of arteries in the transplant recipient's native organs are altered during rejection of lung allografts. The effects are organ specific, may include production of endothelium-derived contractile factors in renal arteries, and can be partially reversed by treatment of rejection.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume39
Issue number6
StatePublished - Jun 1996

Fingerprint

Renal Artery
Endothelium
Allografts
Blood Vessels
Arteries
Dogs
Lung
Pulmonary Artery
Angiotensin I
Calcium Ionophores
Calcimycin
Endothelin-1
Immunosuppression
Smooth Muscle
Coronary Vessels
Leukocytes
Therapeutics
Transplants
Transplant Recipients

Keywords

  • Coronary artery
  • Cyclosporin A
  • Endothelin-1
  • Endothelium-dependent responses
  • Nitric oxide
  • Pulmonary artery
  • Renal artery

ASJC Scopus subject areas

  • Physiology

Cite this

Systemic vascular effects during acute rejection of lung allografts. / Scherstén, Henrik; Tazelaar, Henry D.; Cale, Alexander R J; Miller, Virginia M; McGregor, Christopher G A.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 39, No. 6, 06.1996.

Research output: Contribution to journalArticle

Scherstén, Henrik ; Tazelaar, Henry D. ; Cale, Alexander R J ; Miller, Virginia M ; McGregor, Christopher G A. / Systemic vascular effects during acute rejection of lung allografts. In: American Journal of Physiology - Heart and Circulatory Physiology. 1996 ; Vol. 39, No. 6.
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