Systemic therapy for sarcomatoid renal cell carcinoma

Lance C. Pagliaro; Nizar Tannir; Kanishka Sircar; Eric Jonasch

doi:10.1586/era.11.39

Systemic therapy for sarcomatoid renal cell carcinoma

Lance C. Pagliaro, Nizar Tannir, Kanishka Sircar, Eric Jonasch

Medical Oncology

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney, and sarcomatoid RCC is an aggressive and lethal variant. Sarcomatoid features can be seen in all types of RCC and do not constitute a separate histologic type. No cellular or genetic biomarker for the sarcomatoid variant has yet been discovered. Most systemic therapies developed for metastatic RCC are less effective in sarcomatoid RCC, although some of the cytotoxic drugs may actually be more effective for sarcomatoid RCC because of its rapid rate of proliferation. Several ongoing prospective clinical trials are investigating new drug combinations for this disease.

Original language	English (US)
Pages (from-to)	913-920
Number of pages	8
Journal	Expert review of anticancer therapy
Volume	11
Issue number	6
DOIs	https://doi.org/10.1586/era.11.39
State	Published - Jun 1 2011

Keywords

bevacizumab
chemotherapy
drug therapy
immunotherapy
kidney neoplasm
sarcomatoid neoplasm

ASJC Scopus subject areas

Oncology
Pharmacology (medical)

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title = "Systemic therapy for sarcomatoid renal cell carcinoma",

abstract = "Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney, and sarcomatoid RCC is an aggressive and lethal variant. Sarcomatoid features can be seen in all types of RCC and do not constitute a separate histologic type. No cellular or genetic biomarker for the sarcomatoid variant has yet been discovered. Most systemic therapies developed for metastatic RCC are less effective in sarcomatoid RCC, although some of the cytotoxic drugs may actually be more effective for sarcomatoid RCC because of its rapid rate of proliferation. Several ongoing prospective clinical trials are investigating new drug combinations for this disease.",

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T1 - Systemic therapy for sarcomatoid renal cell carcinoma

AU - Pagliaro, Lance C.

AU - Tannir, Nizar

AU - Sircar, Kanishka

AU - Jonasch, Eric

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney, and sarcomatoid RCC is an aggressive and lethal variant. Sarcomatoid features can be seen in all types of RCC and do not constitute a separate histologic type. No cellular or genetic biomarker for the sarcomatoid variant has yet been discovered. Most systemic therapies developed for metastatic RCC are less effective in sarcomatoid RCC, although some of the cytotoxic drugs may actually be more effective for sarcomatoid RCC because of its rapid rate of proliferation. Several ongoing prospective clinical trials are investigating new drug combinations for this disease.

AB - Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney, and sarcomatoid RCC is an aggressive and lethal variant. Sarcomatoid features can be seen in all types of RCC and do not constitute a separate histologic type. No cellular or genetic biomarker for the sarcomatoid variant has yet been discovered. Most systemic therapies developed for metastatic RCC are less effective in sarcomatoid RCC, although some of the cytotoxic drugs may actually be more effective for sarcomatoid RCC because of its rapid rate of proliferation. Several ongoing prospective clinical trials are investigating new drug combinations for this disease.

KW - bevacizumab

KW - chemotherapy

KW - drug therapy

KW - immunotherapy

KW - kidney neoplasm

KW - sarcomatoid neoplasm

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ER -

Systemic therapy for sarcomatoid renal cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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