Systemic therapy and targeted agents in advanced esophageal cancer

Mark A. Lewis, Harry H Yoon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter summarizes recent progress in the treatment of patients with advanced adenocarcinoma of the esophageal and gastroesophageal junction, with a focus on the clinical development of systemic targeted agents. To date, monoclonal antibodies targeting the human epidermal growth factor receptor (HER) 2 (trastuzumab) and tumor-related angiogenesis (ramucirumab) have been shown to improve overall survival in Phase 3 trials of esophagogastric adenocarcinoma, whereas a lack of meaningful efficacy has been demonstrated by epidermal growth factor receptor (EGFR)-targeted monoclonal antibodies (cetuximab, panitumumab) and small molecule inhibitors (gefitinib). Benefit from the dual EGFR/HER2-targeted tyrosine kinase inhibitor, lapatinib, appears to be limited, although responsive subpopulations may be identified. Success in further development of anti-cancer therapies in advanced disease will likely rely on focusing patient enrollment on those with actionable molecular targets.

Original languageEnglish (US)
Title of host publicationEsophageal Cancer and Barrett's Esophagus
PublisherWiley Blackwell
Pages251-264
Number of pages14
ISBN (Electronic)9781118655153
ISBN (Print)9781118655207
DOIs
StatePublished - Dec 12 2015

Keywords

  • EGFR
  • Esophageal adenocarcinoma
  • Esophageal cancer
  • Gastroesophageal junction adenocarcinoma
  • Gastroesophageal junction cancer
  • HER2
  • Ramucirumab
  • Targeted therapy
  • Trastuzumab

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Systemic therapy and targeted agents in advanced esophageal cancer'. Together they form a unique fingerprint.

Cite this