TY - JOUR
T1 - Systemic Mastocytosis
T2 - Clinical Manifestations and Differential Diagnosis
AU - Butterfield, Joseph H.
PY - 2006/8
Y1 - 2006/8
N2 - Mast cells produce symptoms by local and remote effects of mediator release and by their presence in increased numbers in normal tissue and bone marrow, where they damage and impair normal organ function. Moreover, mast cells are long-lived and heterogeneous in their response to secretagogues and to inhibitors of mediator release. Clinicians sorting out the diagnosis of SM on the basis of presenting signs and symptoms continue to have their diagnostic skills challenged because of the rarity of this disorder, the fact that many symptoms of SM are present in more common disorders, and the multiple guises that SM may assume at the time of presentation.
AB - Mast cells produce symptoms by local and remote effects of mediator release and by their presence in increased numbers in normal tissue and bone marrow, where they damage and impair normal organ function. Moreover, mast cells are long-lived and heterogeneous in their response to secretagogues and to inhibitors of mediator release. Clinicians sorting out the diagnosis of SM on the basis of presenting signs and symptoms continue to have their diagnostic skills challenged because of the rarity of this disorder, the fact that many symptoms of SM are present in more common disorders, and the multiple guises that SM may assume at the time of presentation.
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U2 - 10.1016/j.iac.2006.05.006
DO - 10.1016/j.iac.2006.05.006
M3 - Review article
C2 - 16931290
AN - SCOPUS:33747337010
SN - 0889-8561
VL - 26
SP - 487
EP - 513
JO - Immunology and Allergy Clinics of North America
JF - Immunology and Allergy Clinics of North America
IS - 3
ER -